Peritoneal CD5+ B-1 Cells Have Signaling Properties Similar to Tolerant B Cells

CD5 + B (or B-1) cells are the normal precursors of B cell chronic lymphocytic leukemia. They differ from conventional B (B-2) cells with respect to their phenotype and mitogenic responses and are often secretors of the natural polyreactive antibodies in the serum. The origin of B-1 cells remains co...

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Veröffentlicht in:	The Journal of biological chemistry 2002-08, Vol.277 (34), p.30707-30715
Hauptverfasser:	Wong, Siew-Cheng, Chew, Weng-Keong, Tan, Joy En-Lin, Melendez, Alirio J, Francis, Florence, Lam, Kong-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - physiology CD5 Antigens - analysis DNA-Binding Proteins - metabolism Enzyme Activation Hematopoietic Stem Cells - physiology Immune Tolerance Immunoglobulin M - physiology Immunoglobulin Variable Region - analysis Isoenzymes - metabolism Lymphocyte Activation Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism NFATC Transcription Factors Nuclear Proteins Phospholipase C gamma Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Receptors, Antigen, B-Cell - physiology Transcription Factors - metabolism Type C Phospholipases - metabolism
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