Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain

It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES)...

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Veröffentlicht in:	Neuroreport 2004-06, Vol.15 (9), p.1395-1398
Hauptverfasser:	Mabuchi, Tamaki, Kojima, Hiroyuki, Abe, Tetsuya, Takagi, Kunio, Sakurai, Madoka, Ohmiya, Yoshihiro, Uematsu, Satoshi, Akira, Shizuo, Watanabe, Kikuko, Ito, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Denervation Dinoprostone - metabolism Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Neuralgia - metabolism Neuralgia - physiopathology Prostaglandin-E Synthases RNA, Messenger - analysis Spinal Nerves - physiology
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