Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain
It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES)...
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| Veröffentlicht in: | Neuroreport 2004-06, Vol.15 (9), p.1395-1398 |
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| creator | Mabuchi, Tamaki Kojima, Hiroyuki Abe, Tetsuya Takagi, Kunio Sakurai, Madoka Ohmiya, Yoshihiro Uematsu, Satoshi Akira, Shizuo Watanabe, Kikuko Ito, Seiji |
| description | It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2. In the present study, to clarify the involvement of PGE2 and identify PGES mediating neuropathic pain, we applied a neuropathic pain model prepared by L5 spinal nerve transection to mPGES-1 knockout (mPGES-1) mice. Whereas they retained normal nociceptive responses, mPGES-1 mice did not exhibit mechanical allodynia and thermal hyperalgesia over a week. These results demonstrate that PGE2 produced by mPGES-1 is involved in neuropathic pain. |
| doi_str_mv | 10.1097/01.wnr.0000129372.89000.31 |
| format | Article |
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However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2. In the present study, to clarify the involvement of PGE2 and identify PGES mediating neuropathic pain, we applied a neuropathic pain model prepared by L5 spinal nerve transection to mPGES-1 knockout (mPGES-1) mice. Whereas they retained normal nociceptive responses, mPGES-1 mice did not exhibit mechanical allodynia and thermal hyperalgesia over a week. 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These results demonstrate that PGE2 produced by mPGES-1 is involved in neuropathic pain.</description><subject>Animals</subject><subject>Denervation</subject><subject>Dinoprostone - metabolism</subject><subject>Intramolecular Oxidoreductases - genetics</subject><subject>Intramolecular Oxidoreductases - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neuralgia - metabolism</subject><subject>Neuralgia - physiopathology</subject><subject>Prostaglandin-E Synthases</subject><subject>RNA, Messenger - analysis</subject><subject>Spinal Nerves - physiology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1PxCAQhonR6PrxF0zjwRuVodAWb8asH4nGiybeCIXBrXbbFdps_Pey7iZygUyemXl5CLkAlgNT1RWDfN2HnKUDXBUVz2uV3nkBe2QGoiqolPX7PpkxJRUVqpRH5DjGz8QoBvUhOQIJStQlm5GXZ1w2wfRITYyDbc2ILluFIY7mozO9a_tsnsWfflyYiBSyNmYBv6c2JMwPIetxCsPKjIvWZivT9qfkwJsu4tnuPiFvd_PX2wf69HL_eHvzRC1nlaSFwMYjWvRouUVurLe8qRx4L0E0heOWg8XGGel9UwvHseS-5tw1qnScFSfkcjs3Zf2eMI562UaLXcqMwxR1xRlUQm3A6y1o06diQK9XoV2a8KOB6Y1OzUAnnfpfp_7TqQtIzee7LVOzRPffuvOXALEF1kM3Yohf3bTGoBdounGxHVnJknLGBCt5zeimJItfRMmENQ</recordid><startdate>20040628</startdate><enddate>20040628</enddate><creator>Mabuchi, Tamaki</creator><creator>Kojima, Hiroyuki</creator><creator>Abe, Tetsuya</creator><creator>Takagi, Kunio</creator><creator>Sakurai, Madoka</creator><creator>Ohmiya, Yoshihiro</creator><creator>Uematsu, Satoshi</creator><creator>Akira, Shizuo</creator><creator>Watanabe, Kikuko</creator><creator>Ito, Seiji</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040628</creationdate><title>Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain</title><author>Mabuchi, Tamaki ; Kojima, Hiroyuki ; Abe, Tetsuya ; Takagi, Kunio ; Sakurai, Madoka ; Ohmiya, Yoshihiro ; Uematsu, Satoshi ; Akira, Shizuo ; Watanabe, Kikuko ; Ito, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2075-34ebfeecefec2ce2acfc2b7d1ff514b3d2c21cebda5ffb84d2e62f822db96d203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Denervation</topic><topic>Dinoprostone - metabolism</topic><topic>Intramolecular Oxidoreductases - genetics</topic><topic>Intramolecular Oxidoreductases - metabolism</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neuralgia - metabolism</topic><topic>Neuralgia - physiopathology</topic><topic>Prostaglandin-E Synthases</topic><topic>RNA, Messenger - analysis</topic><topic>Spinal Nerves - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mabuchi, Tamaki</creatorcontrib><creatorcontrib>Kojima, Hiroyuki</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Takagi, Kunio</creatorcontrib><creatorcontrib>Sakurai, Madoka</creatorcontrib><creatorcontrib>Ohmiya, Yoshihiro</creatorcontrib><creatorcontrib>Uematsu, Satoshi</creatorcontrib><creatorcontrib>Akira, Shizuo</creatorcontrib><creatorcontrib>Watanabe, Kikuko</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mabuchi, Tamaki</au><au>Kojima, Hiroyuki</au><au>Abe, Tetsuya</au><au>Takagi, Kunio</au><au>Sakurai, Madoka</au><au>Ohmiya, Yoshihiro</au><au>Uematsu, Satoshi</au><au>Akira, Shizuo</au><au>Watanabe, Kikuko</au><au>Ito, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2004-06-28</date><risdate>2004</risdate><volume>15</volume><issue>9</issue><spage>1395</spage><epage>1398</epage><pages>1395-1398</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2. In the present study, to clarify the involvement of PGE2 and identify PGES mediating neuropathic pain, we applied a neuropathic pain model prepared by L5 spinal nerve transection to mPGES-1 knockout (mPGES-1) mice. Whereas they retained normal nociceptive responses, mPGES-1 mice did not exhibit mechanical allodynia and thermal hyperalgesia over a week. These results demonstrate that PGE2 produced by mPGES-1 is involved in neuropathic pain.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15194860</pmid><doi>10.1097/01.wnr.0000129372.89000.31</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Denervation Dinoprostone - metabolism Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Neuralgia - metabolism Neuralgia - physiopathology Prostaglandin-E Synthases RNA, Messenger - analysis Spinal Nerves - physiology |
| title | Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain |
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