Repercussions of extensive small bowel resections in growing rats
To study the effects of extensive intestinal resection on growing rats, with regard to animal weight and histomorphometry of the remaining small intestine. Forty growing rats were allocated according to the extent of small intestine resection: 60%, 70%, 80%, or 90%. The animals were weighed every we...
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| Veröffentlicht in: | Transplantation proceedings 2004-05, Vol.36 (4), p.1009-1011 |
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| creator | Lanzoni, N Martins, J.L Montero, E.F.S Patrício, F.R.S Juliano, Y |
| description | To study the effects of extensive intestinal resection on growing rats, with regard to animal weight and histomorphometry of the remaining small intestine.
Forty growing rats were allocated according to the extent of small intestine resection: 60%, 70%, 80%, or 90%. The animals were weighed every week and observed for 30 days. Following sacrifice the remaining small intestine was resected, fixed in 10% formol for 24 hours, embedded in paraffin, and stained using hematoxylin and eosin. The histological changes in the remaining small intestine were assessed for the length and thickness of villi, the thickness of the muscle layer, and the number of intestinal glands.
All growing rats showed a fall in body weight, although it was more significant with the largest intestinal resection (80% and 90%). Villus length and muscle thickness increased after 30 postoperative days in all rats, but the number of intestinal glands remained unaltered.
Growing rats with greatest resection of small intestine (80% and 90%) had better intestinal adaptation and slower recovery of body weight. |
| doi_str_mv | 10.1016/j.transproceed.2004.03.048 |
| format | Article |
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Forty growing rats were allocated according to the extent of small intestine resection: 60%, 70%, 80%, or 90%. The animals were weighed every week and observed for 30 days. Following sacrifice the remaining small intestine was resected, fixed in 10% formol for 24 hours, embedded in paraffin, and stained using hematoxylin and eosin. The histological changes in the remaining small intestine were assessed for the length and thickness of villi, the thickness of the muscle layer, and the number of intestinal glands.
All growing rats showed a fall in body weight, although it was more significant with the largest intestinal resection (80% and 90%). Villus length and muscle thickness increased after 30 postoperative days in all rats, but the number of intestinal glands remained unaltered.
Growing rats with greatest resection of small intestine (80% and 90%) had better intestinal adaptation and slower recovery of body weight.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.03.048</identifier><identifier>PMID: 15194351</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Intestinal Mucosa - cytology ; Intestinal Mucosa - pathology ; Intestinal Mucosa - transplantation ; Intestine, Small - cytology ; Intestine, Small - pathology ; Intestine, Small - transplantation ; Male ; Medical sciences ; Microvilli - ultrastructure ; Models, Animal ; Postoperative Period ; Rats ; Rats, Wistar ; Stomach, duodenum, intestine, rectum, anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>Transplantation proceedings, 2004-05, Vol.36 (4), p.1009-1011</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-57d1e8bf39d73fd7cc76b62569e2f768892a55a321fd0d4cf99aa562a93688ba3</citedby><cites>FETCH-LOGICAL-c406t-57d1e8bf39d73fd7cc76b62569e2f768892a55a321fd0d4cf99aa562a93688ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134504003094$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15870669$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15194351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lanzoni, N</creatorcontrib><creatorcontrib>Martins, J.L</creatorcontrib><creatorcontrib>Montero, E.F.S</creatorcontrib><creatorcontrib>Patrício, F.R.S</creatorcontrib><creatorcontrib>Juliano, Y</creatorcontrib><title>Repercussions of extensive small bowel resections in growing rats</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>To study the effects of extensive intestinal resection on growing rats, with regard to animal weight and histomorphometry of the remaining small intestine.
Forty growing rats were allocated according to the extent of small intestine resection: 60%, 70%, 80%, or 90%. The animals were weighed every week and observed for 30 days. Following sacrifice the remaining small intestine was resected, fixed in 10% formol for 24 hours, embedded in paraffin, and stained using hematoxylin and eosin. The histological changes in the remaining small intestine were assessed for the length and thickness of villi, the thickness of the muscle layer, and the number of intestinal glands.
All growing rats showed a fall in body weight, although it was more significant with the largest intestinal resection (80% and 90%). Villus length and muscle thickness increased after 30 postoperative days in all rats, but the number of intestinal glands remained unaltered.
Growing rats with greatest resection of small intestine (80% and 90%) had better intestinal adaptation and slower recovery of body weight.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - transplantation</subject><subject>Intestine, Small - cytology</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microvilli - ultrastructure</subject><subject>Models, Animal</subject><subject>Postoperative Period</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFtLwzAUx4MoOi9fQYqgb625tEnr2_AOA0H0OaTpycjo2pnTOf32Zm7IHn06hP_vXPIj5ILRjFEmr2fZEEyHi9BbgCbjlOYZFRnNyz0yYqUSKZdc7JNRDFjKRF4ckWPEGY1vnotDcsQKVuWiYCMyfoUFBLtE9H2HSe8S-BqgQ_8JCc5N2yZ1v4I2CYBgh1_Gd8k09CvfTZNgBjwlB860CGfbekLeH-7fbp_Sycvj8-14ktqcyiEtVMOgrJ2oGiVco6xVspa8kBVwp2RZVtwUhRGcuYY2uXVVZUwhualEDGsjTsjVZm7898cScNBzjxba1nTQL1ErTpniuYzgzQa0oUcM4PQi-LkJ35pRvRaoZ3pXoF4L1FToKDA2n2-3LOt5zP5at8YicLkFDFrTujjIetzhSkWlrCJ3t-EgOvn0EDRaD52FxodoUje9_889P60yll0</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Lanzoni, N</creator><creator>Martins, J.L</creator><creator>Montero, E.F.S</creator><creator>Patrício, F.R.S</creator><creator>Juliano, Y</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Repercussions of extensive small bowel resections in growing rats</title><author>Lanzoni, N ; Martins, J.L ; Montero, E.F.S ; Patrício, F.R.S ; Juliano, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-57d1e8bf39d73fd7cc76b62569e2f768892a55a321fd0d4cf99aa562a93688ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - transplantation</topic><topic>Intestine, Small - cytology</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microvilli - ultrastructure</topic><topic>Models, Animal</topic><topic>Postoperative Period</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lanzoni, N</creatorcontrib><creatorcontrib>Martins, J.L</creatorcontrib><creatorcontrib>Montero, E.F.S</creatorcontrib><creatorcontrib>Patrício, F.R.S</creatorcontrib><creatorcontrib>Juliano, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lanzoni, N</au><au>Martins, J.L</au><au>Montero, E.F.S</au><au>Patrício, F.R.S</au><au>Juliano, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repercussions of extensive small bowel resections in growing rats</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>36</volume><issue>4</issue><spage>1009</spage><epage>1011</epage><pages>1009-1011</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>To study the effects of extensive intestinal resection on growing rats, with regard to animal weight and histomorphometry of the remaining small intestine.
Forty growing rats were allocated according to the extent of small intestine resection: 60%, 70%, 80%, or 90%. The animals were weighed every week and observed for 30 days. Following sacrifice the remaining small intestine was resected, fixed in 10% formol for 24 hours, embedded in paraffin, and stained using hematoxylin and eosin. The histological changes in the remaining small intestine were assessed for the length and thickness of villi, the thickness of the muscle layer, and the number of intestinal glands.
All growing rats showed a fall in body weight, although it was more significant with the largest intestinal resection (80% and 90%). Villus length and muscle thickness increased after 30 postoperative days in all rats, but the number of intestinal glands remained unaltered.
Growing rats with greatest resection of small intestine (80% and 90%) had better intestinal adaptation and slower recovery of body weight.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15194351</pmid><doi>10.1016/j.transproceed.2004.03.048</doi><tpages>3</tpages></addata></record> |
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| ispartof | Transplantation proceedings, 2004-05, Vol.36 (4), p.1009-1011 |
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| subjects | Animals Biological and medical sciences Body Weight Intestinal Mucosa - cytology Intestinal Mucosa - pathology Intestinal Mucosa - transplantation Intestine, Small - cytology Intestine, Small - pathology Intestine, Small - transplantation Male Medical sciences Microvilli - ultrastructure Models, Animal Postoperative Period Rats Rats, Wistar Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Repercussions of extensive small bowel resections in growing rats |
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