The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
ADAMTS-1 is an ECM-anchored metalloproteinase with proteoglycan-degrading activity as well as an angiogenesis inhibiting activity. Here, we examined the effects of ADAMTS-1 overexpression on in vivo tumor growth and tumor metastasis. Overexpression of only the C-terminal half region of ADAMTS-1, con...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2004-07, Vol.319 (4), p.1327-1333 |
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| creator | Kuno, Kouji Bannai, Kenji Hakozaki, Michinori Matsushima, Kouji Hirose, Kunitaka |
| description | ADAMTS-1 is an ECM-anchored metalloproteinase with proteoglycan-degrading activity as well as an angiogenesis inhibiting activity. Here, we examined the effects of ADAMTS-1 overexpression on in vivo tumor growth and tumor metastasis. Overexpression of only the C-terminal half region of ADAMTS-1, consisting of TSP type I motifs and the spacer region, suppressed Chinese hamster ovary (CHO) tumor growth in mice. In addition, a significant reduction in tumor metastatic potential was observed in ADAMTS-1-transfected CHO cells in an experimental metastasis assay. Furthermore, deletional analyses revealed that the C-terminal half region of ADAMTS-1 is responsible for its experimental metastasis–inhibitory activity. Our data suggest that the C-terminal half region of ADAMTS-1 has therapeutic potential as an inhibitor of tumor growth and metastasis. |
| doi_str_mv | 10.1016/j.bbrc.2004.05.105 |
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Here, we examined the effects of ADAMTS-1 overexpression on in vivo tumor growth and tumor metastasis. Overexpression of only the C-terminal half region of ADAMTS-1, consisting of TSP type I motifs and the spacer region, suppressed Chinese hamster ovary (CHO) tumor growth in mice. In addition, a significant reduction in tumor metastatic potential was observed in ADAMTS-1-transfected CHO cells in an experimental metastasis assay. Furthermore, deletional analyses revealed that the C-terminal half region of ADAMTS-1 is responsible for its experimental metastasis–inhibitory activity. Our data suggest that the C-terminal half region of ADAMTS-1 has therapeutic potential as an inhibitor of tumor growth and metastasis.</description><subject>ADAM</subject><subject>ADAM Proteins</subject><subject>ADAMTS1 Protein</subject><subject>Amino Acid Motifs</subject><subject>Animals</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Disintegrins - chemistry</subject><subject>Disintegrins - genetics</subject><subject>Disintegrins - metabolism</subject><subject>Extracellular matrix</subject><subject>Lung - cytology</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Metalloendopeptidases - chemistry</subject><subject>Metalloendopeptidases - genetics</subject><subject>Metalloendopeptidases - metabolism</subject><subject>Metalloproteinase</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - genetics</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neovascularization, Pathologic</subject><subject>Tumor growth</subject><subject>Tumor metastasis</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9rGzEUxEVpady0X6CHolNv6-rJ0q4FvZik_yChh7jQm5C0b2OZ3dVW0hb720euDb3l9GDezMD8CHkPbAkM6k_7pbXRLTljYslk0eQLsgCmWMWBiZdkwRirK67g9xV5k9KeMQBRq9fkCiQoIWG1IIftDqkz0YbDsa8yxsGPpqc703c04qMPIw0d3dxu7rcPFdA0T1PElDBRG_KO5nkI0T_i6J3PR2rGluJhwugHHHPp-fenA2aTssne0Snk8vGmf0tedaZP-O5yr8mvr1-2N9-ru5_fftxs7ionYJ0rcNB2reNrhZ2x6xpqzpQybqWg5azpOiOccCtuOmPcWlhTN03NpARpuW1atbomH8-9Uwx_ZkxZDz457HszYpiTbnhBKZUoRn42uhhSitjpqcww8aiB6RNvvdcn3vrEWzNZNFlCHy7tsx2w_R-5AC6Gz2cDlo1_PUadnMfRYesjuqzb4J_rfwLF_pP7</recordid><startdate>20040709</startdate><enddate>20040709</enddate><creator>Kuno, Kouji</creator><creator>Bannai, Kenji</creator><creator>Hakozaki, Michinori</creator><creator>Matsushima, Kouji</creator><creator>Hirose, Kunitaka</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040709</creationdate><title>The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential</title><author>Kuno, Kouji ; Bannai, Kenji ; Hakozaki, Michinori ; Matsushima, Kouji ; Hirose, Kunitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1c1dfdc289efab86162099ac391d207ffa4c4c32afaac84ba677605515b2b7d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>ADAM</topic><topic>ADAM Proteins</topic><topic>ADAMTS1 Protein</topic><topic>Amino Acid Motifs</topic><topic>Animals</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Disintegrins - chemistry</topic><topic>Disintegrins - genetics</topic><topic>Disintegrins - metabolism</topic><topic>Extracellular matrix</topic><topic>Lung - cytology</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Metalloendopeptidases - chemistry</topic><topic>Metalloendopeptidases - genetics</topic><topic>Metalloendopeptidases - metabolism</topic><topic>Metalloproteinase</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - genetics</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neovascularization, Pathologic</topic><topic>Tumor growth</topic><topic>Tumor metastasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuno, Kouji</creatorcontrib><creatorcontrib>Bannai, Kenji</creatorcontrib><creatorcontrib>Hakozaki, Michinori</creatorcontrib><creatorcontrib>Matsushima, Kouji</creatorcontrib><creatorcontrib>Hirose, Kunitaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuno, Kouji</au><au>Bannai, Kenji</au><au>Hakozaki, Michinori</au><au>Matsushima, Kouji</au><au>Hirose, Kunitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-07-09</date><risdate>2004</risdate><volume>319</volume><issue>4</issue><spage>1327</spage><epage>1333</epage><pages>1327-1333</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>ADAMTS-1 is an ECM-anchored metalloproteinase with proteoglycan-degrading activity as well as an angiogenesis inhibiting activity. Here, we examined the effects of ADAMTS-1 overexpression on in vivo tumor growth and tumor metastasis. Overexpression of only the C-terminal half region of ADAMTS-1, consisting of TSP type I motifs and the spacer region, suppressed Chinese hamster ovary (CHO) tumor growth in mice. In addition, a significant reduction in tumor metastatic potential was observed in ADAMTS-1-transfected CHO cells in an experimental metastasis assay. Furthermore, deletional analyses revealed that the C-terminal half region of ADAMTS-1 is responsible for its experimental metastasis–inhibitory activity. Our data suggest that the C-terminal half region of ADAMTS-1 has therapeutic potential as an inhibitor of tumor growth and metastasis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15194513</pmid><doi>10.1016/j.bbrc.2004.05.105</doi><tpages>7</tpages></addata></record> |
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| subjects | ADAM ADAM Proteins ADAMTS1 Protein Amino Acid Motifs Animals CHO Cells Cricetinae Disintegrins - chemistry Disintegrins - genetics Disintegrins - metabolism Extracellular matrix Lung - cytology Lung - metabolism Lung - pathology Male Metalloendopeptidases - chemistry Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Metalloproteinase Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis Neoplasm Transplantation Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neovascularization, Pathologic Tumor growth Tumor metastasis |
| title | The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential |
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