Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells
Herein we report mechanisms whereby Flt3 ligand (FL) augments steady state T cell activity in addition to the expansion of dendritic cells (DCs). We demonstrate that in vivo administration of FL increases the frequency and absolute number of effector/memory T cells and preferentially expands T cells...
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| Veröffentlicht in: | International immunopharmacology 2002-06, Vol.2 (7), p.925-940 |
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| container_title | International immunopharmacology |
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| creator | Lee Mosley, R Parajuli, Prahlad Pisarev, Vladimir Chavez, Jennifer Meeks, Amy Steffel, Amy Leutzinger, Cheryl Talmadge, James E |
| description | Herein we report mechanisms whereby Flt3 ligand (FL) augments steady state T cell activity in addition to the expansion of dendritic cells (DCs). We demonstrate that in vivo administration of FL increases the frequency and absolute number of effector/memory T cells and preferentially expands T cells that express a type-1 cytokine phenotype. In addition, FL enhances T cell proliferative responses to Concanavalin A that directly correlated with increased frequencies in effector/memory T cells and expansion of lymphoid-derived (type 1) DCs (DC1s). Together, these data demonstrate that mechanisms of FL-induced T cell regulation include not only the expansion of DC subsets, but also the preferential expansion of type 1-effector/memory T cell populations, and suggest multiple mechanisms of action for FL as a vaccine adjuvant and as a therapeutic modality. |
| doi_str_mv | 10.1016/S1567-5769(02)00035-8 |
| format | Article |
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We demonstrate that in vivo administration of FL increases the frequency and absolute number of effector/memory T cells and preferentially expands T cells that express a type-1 cytokine phenotype. In addition, FL enhances T cell proliferative responses to Concanavalin A that directly correlated with increased frequencies in effector/memory T cells and expansion of lymphoid-derived (type 1) DCs (DC1s). 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Drug treatments ; Spleen - cytology ; Spleen - drug effects ; Spleen - metabolism ; T cells ; T-Lymphocytes - cytology ; T-Lymphocytes - enzymology ; T-Lymphocytes - metabolism ; Th1 Cells - cytology ; Th1 Cells - physiology</subject><ispartof>International immunopharmacology, 2002-06, Vol.2 (7), p.925-940</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-690489abaed2b2c9f30bbaa2af1f4eb2c76dd80f6caac515172d12340c6821b13</citedby><cites>FETCH-LOGICAL-c422t-690489abaed2b2c9f30bbaa2af1f4eb2c76dd80f6caac515172d12340c6821b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1567-5769(02)00035-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13771741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12188034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee Mosley, R</creatorcontrib><creatorcontrib>Parajuli, Prahlad</creatorcontrib><creatorcontrib>Pisarev, Vladimir</creatorcontrib><creatorcontrib>Chavez, Jennifer</creatorcontrib><creatorcontrib>Meeks, Amy</creatorcontrib><creatorcontrib>Steffel, Amy</creatorcontrib><creatorcontrib>Leutzinger, Cheryl</creatorcontrib><creatorcontrib>Talmadge, James E</creatorcontrib><title>Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Herein we report mechanisms whereby Flt3 ligand (FL) augments steady state T cell activity in addition to the expansion of dendritic cells (DCs). We demonstrate that in vivo administration of FL increases the frequency and absolute number of effector/memory T cells and preferentially expands T cells that express a type-1 cytokine phenotype. In addition, FL enhances T cell proliferative responses to Concanavalin A that directly correlated with increased frequencies in effector/memory T cells and expansion of lymphoid-derived (type 1) DCs (DC1s). Together, these data demonstrate that mechanisms of FL-induced T cell regulation include not only the expansion of DC subsets, but also the preferential expansion of type 1-effector/memory T cell populations, and suggest multiple mechanisms of action for FL as a vaccine adjuvant and as a therapeutic modality.</description><subject>Adjuvants, Immunologic - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - metabolism</subject><subject>Female</subject><subject>Flt3 ligand</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Interferon-γ</subject><subject>Interleukin-4</subject><subject>Medical sciences</subject><subject>Membrane Proteins - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitosis - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>Spleen - metabolism</subject><subject>T cells</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - enzymology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - physiology</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQha2qiJbCTyjypQgOoTNOHDunqqpYQKrEgXLFcpzxyiiJFzuL2H9P0g3qsSePRt8bz7zH2CXCRwSsr7-jrFUhVd28B_EBAEpZ6BN2jlrpAhXI07n-j5yxVzn_Apj7Fb5kZyhQayirc_Zz008l78PWjh23--1A42SnEEcePX_gjvqeD2GKWxoph8wXjP7u7JhXZjrsiCMn78lNMV0PNMR0WKX5NXvhbZ_pzfpesB-bTw93X4r7b5-_3t3eF64SYirqBird2NZSJ1rhGl9C21orrEdf0dxRdddp8LWz1kmUqESHoqzA1Vpgi-UFe3ecu0vx957yZIaQlw3sSHGfjRKAUlbyWRC11GUDzQzKI-hSzDmRN7sUBpsOBsEsCZjHBMxirwFhHhMweta9XT_YtwN1T6rV8hm4WgGbne19sqML-YkrlUJVLSfdHDmaffsTKJnsAo2OupBmq00XwzOr_AMF4KJ2</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Lee Mosley, R</creator><creator>Parajuli, Prahlad</creator><creator>Pisarev, Vladimir</creator><creator>Chavez, Jennifer</creator><creator>Meeks, Amy</creator><creator>Steffel, Amy</creator><creator>Leutzinger, Cheryl</creator><creator>Talmadge, James E</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells</title><author>Lee Mosley, R ; Parajuli, Prahlad ; Pisarev, Vladimir ; Chavez, Jennifer ; Meeks, Amy ; Steffel, Amy ; Leutzinger, Cheryl ; Talmadge, James E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-690489abaed2b2c9f30bbaa2af1f4eb2c76dd80f6caac515172d12340c6821b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adjuvants, Immunologic - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytokines - biosynthesis</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - metabolism</topic><topic>Female</topic><topic>Flt3 ligand</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Interferon-γ</topic><topic>Interleukin-4</topic><topic>Medical sciences</topic><topic>Membrane Proteins - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitosis - physiology</topic><topic>Pharmacology. 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| subjects | Adjuvants, Immunologic - physiology Animals Biological and medical sciences Cytokines - biosynthesis Dendritic cells Dendritic Cells - cytology Dendritic Cells - metabolism Female Flt3 ligand Humans Immunomodulators Interferon-γ Interleukin-4 Medical sciences Membrane Proteins - physiology Mice Mice, Inbred BALB C Mitosis - physiology Pharmacology. Drug treatments Spleen - cytology Spleen - drug effects Spleen - metabolism T cells T-Lymphocytes - cytology T-Lymphocytes - enzymology T-Lymphocytes - metabolism Th1 Cells - cytology Th1 Cells - physiology |
| title | Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells |
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