Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients
The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations. One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2002-08, Vol.240 (8), p.658-665 |
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| creator | HORN, Folkert K WAKILI, Nina JÜNEMANN, Anselm M KORTH, Matthias |
| description | The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations.
One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry.
Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P |
| doi_str_mv | 10.1007/s00417-002-0512-9 |
| format | Article |
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One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry.
Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P<0.001). Using a predefined specificity of 96% in control eyes, 11% of ocular hypertensive eyes, 28.5% of "preperimetric" glaucoma eyes and 86.9% of "perimetric" glaucoma eyes have been classified glaucomatous using an overall score and with consideration of different cut-off points in right and left eyes.
Point-wise analysis of FDT screening results can be helpful for classification of patient groups and consideration of the individual learning curve in repeated measurements. The C-20-5 protocol of the FDT perimeter is able to detect a considerable proportion of glaucomatous patients.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-002-0512-9</identifier><identifier>PMID: 12192460</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; False Positive Reactions ; Female ; Glaucoma ; Glaucoma and intraocular pressure ; Glaucoma, Open-Angle - diagnosis ; Humans ; Male ; Medical sciences ; Middle Aged ; Ocular Hypertension - diagnosis ; Ophthalmology ; Predictive Value of Tests ; Reproducibility of Results ; Sensitivity and Specificity ; Vision Disorders - diagnosis ; Visual Field Tests - methods ; Visual Fields</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2002-08, Vol.240 (8), p.658-665</ispartof><rights>2002 INIST-CNRS</rights><rights>Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-7d3bfeee57e7daa6e6154037c275e23d2d043658b6b15fec5921f1b496df77023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13876629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12192460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HORN, Folkert K</creatorcontrib><creatorcontrib>WAKILI, Nina</creatorcontrib><creatorcontrib>JÜNEMANN, Anselm M</creatorcontrib><creatorcontrib>KORTH, Matthias</creatorcontrib><title>Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations.
One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry.
Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P<0.001). Using a predefined specificity of 96% in control eyes, 11% of ocular hypertensive eyes, 28.5% of "preperimetric" glaucoma eyes and 86.9% of "perimetric" glaucoma eyes have been classified glaucomatous using an overall score and with consideration of different cut-off points in right and left eyes.
Point-wise analysis of FDT screening results can be helpful for classification of patient groups and consideration of the individual learning curve in repeated measurements. The C-20-5 protocol of the FDT perimeter is able to detect a considerable proportion of glaucomatous patients.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma and intraocular pressure</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ocular Hypertension - diagnosis</subject><subject>Ophthalmology</subject><subject>Predictive Value of Tests</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Vision Disorders - diagnosis</subject><subject>Visual Field Tests - methods</subject><subject>Visual Fields</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU9r4zAQxUXZ0qbZ_QC9FLPQnqquNLKs-LiE_oNCL13oTcjyKHGxpaxkd8m3r0ICgT0JRr_3mDePkEvO7jhj6ldirOSKMgaUSQ60PiEzXgpJFYP3b2TGFHC6EPB-Ti5S-mAZF5KfkXMOvIayYjPi3zCNnV8VLsRi1ZvJhsEU_7pxXbiIfyf0dkvbMDX9Dtpg7AYc47bofOFDHEyfbotgp97EYr3N3yP61H1inhrfHg03ZuzQj-k7OXVZgz8O75z8ebh_Wz7Rl9fH5-XvF2qFLEeqWtE4RJQKVWtMhRWXJRPKgpIIooU2J6nkoqkaLh1aWQN3vCnrqnUqhxdzcrP33cSQQ6RRD12y2PfGY5iSVsC4BLXI4M__wI8wRZ930yCYUgClzBDfQzaGlCI6vcl3MHGrOdO7JvS-CZ2b0LsmdJ01VwfjqRmwPSoOp8_A9QEwyZreReNtl46cWKiqglp8ATQzkj8</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>HORN, Folkert K</creator><creator>WAKILI, Nina</creator><creator>JÜNEMANN, Anselm M</creator><creator>KORTH, Matthias</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients</title><author>HORN, Folkert K ; WAKILI, Nina ; JÜNEMANN, Anselm M ; KORTH, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-7d3bfeee57e7daa6e6154037c275e23d2d043658b6b15fec5921f1b496df77023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma and intraocular pressure</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ocular Hypertension - diagnosis</topic><topic>Ophthalmology</topic><topic>Predictive Value of Tests</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Vision Disorders - diagnosis</topic><topic>Visual Field Tests - methods</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HORN, Folkert K</creatorcontrib><creatorcontrib>WAKILI, Nina</creatorcontrib><creatorcontrib>JÜNEMANN, Anselm M</creatorcontrib><creatorcontrib>KORTH, Matthias</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HORN, Folkert K</au><au>WAKILI, Nina</au><au>JÜNEMANN, Anselm M</au><au>KORTH, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>240</volume><issue>8</issue><spage>658</spage><epage>665</epage><pages>658-665</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><coden>GACODL</coden><abstract>The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations.
One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry.
Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P<0.001). Using a predefined specificity of 96% in control eyes, 11% of ocular hypertensive eyes, 28.5% of "preperimetric" glaucoma eyes and 86.9% of "perimetric" glaucoma eyes have been classified glaucomatous using an overall score and with consideration of different cut-off points in right and left eyes.
Point-wise analysis of FDT screening results can be helpful for classification of patient groups and consideration of the individual learning curve in repeated measurements. The C-20-5 protocol of the FDT perimeter is able to detect a considerable proportion of glaucomatous patients.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12192460</pmid><doi>10.1007/s00417-002-0512-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2002-08, Vol.240 (8), p.658-665 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Biological and medical sciences False Positive Reactions Female Glaucoma Glaucoma and intraocular pressure Glaucoma, Open-Angle - diagnosis Humans Male Medical sciences Middle Aged Ocular Hypertension - diagnosis Ophthalmology Predictive Value of Tests Reproducibility of Results Sensitivity and Specificity Vision Disorders - diagnosis Visual Field Tests - methods Visual Fields |
| title | Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients |
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