Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine
To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per...
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| Veröffentlicht in: | The Journal of pediatrics 2004-06, Vol.144 (6), p.747-752 |
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| creator | SIMONFAU-ROY, J MARTI, S DEAL, C HUOT, C ROBAEY, P VAN VLIET, Guy |
| description | To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per day of levothyroxine were evaluated at 5 years, 9 months, with the McCarthy Scale and the Questionnaire for Evaluation of Social Behavior, as were 40 control children.
The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P=.02) and inattention (P=.05), whereas the number of times TSH was |
| doi_str_mv | 10.1016/S0022-3476(04)00142-8 |
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The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P=.02) and inattention (P=.05), whereas the number of times TSH was <0.8 mIU/L was correlated with lower verbal scores (P=.05).
Children with severe CH treated early with a high dose of levothyroxine have normal global development and behavior at school entry.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(04)00142-8</identifier><identifier>PMID: 15192621</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Analysis of Variance ; Biological and medical sciences ; Child Behavior Disorders - epidemiology ; Child Behavior Disorders - prevention & control ; Child, Preschool ; Cognition - drug effects ; Congenital Hypothyroidism ; Developmental Disabilities - epidemiology ; Developmental Disabilities - prevention & control ; Dose-Response Relationship, Drug ; Endocrinopathies ; Female ; General aspects ; Humans ; Hypothyroidism - drug therapy ; Infant, Newborn ; Male ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Prospective Studies ; Quebec - epidemiology ; Severity of Illness Index ; Statistics, Nonparametric ; Thyroid. Thyroid axis (diseases) ; Thyroxine - administration & dosage ; Thyroxine - pharmacology</subject><ispartof>The Journal of pediatrics, 2004-06, Vol.144 (6), p.747-752</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1821-a4c6306dd215c133575844a5316b1f1315167065f90608957b2f424b9ebc7da63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15871432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15192621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SIMONFAU-ROY, J</creatorcontrib><creatorcontrib>MARTI, S</creatorcontrib><creatorcontrib>DEAL, C</creatorcontrib><creatorcontrib>HUOT, C</creatorcontrib><creatorcontrib>ROBAEY, P</creatorcontrib><creatorcontrib>VAN VLIET, Guy</creatorcontrib><title>Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per day of levothyroxine were evaluated at 5 years, 9 months, with the McCarthy Scale and the Questionnaire for Evaluation of Social Behavior, as were 40 control children.
The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P=.02) and inattention (P=.05), whereas the number of times TSH was <0.8 mIU/L was correlated with lower verbal scores (P=.05).
Children with severe CH treated early with a high dose of levothyroxine have normal global development and behavior at school entry.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child Behavior Disorders - epidemiology</subject><subject>Child Behavior Disorders - prevention & control</subject><subject>Child, Preschool</subject><subject>Cognition - drug effects</subject><subject>Congenital Hypothyroidism</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Developmental Disabilities - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypothyroidism - drug therapy</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Prospective Studies</subject><subject>Quebec - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroxine - administration & dosage</subject><subject>Thyroxine - pharmacology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0E-P1CAYx3FiNO64-hI0XDR6qD4PUGiPZuK_ZBMP6plQoFMMAyN0Vpv44u3sTNQTl88PwpeQpwivEVC--QLAWMOFki9BvAJAwZruHtkg9KqRHef3yeYvuSKPav0OAL0AeEiusMWeSYYb8nubdynMISdqkqODn8xtyIWamVY75RypT3NZaEjUTiG64hP9GeaJ2px2fl2aSKflkOdpKTm4UPd0Lt7M3lFvSlzOeAq7qXG5ehr97dn-Csk_Jg9GE6t_cjmvybf3775uPzY3nz982r69aSx2DBsjrOQgnWPYWuS8VW0nhGk5ygFH5OtvpALZjj1I6PpWDWwUTAy9H6xyRvJr8uJ876HkH0dfZ70P1foYTfL5WLViaz7Vdytsz9CWXGvxoz6UsDdl0Qj6lF3fZdenphqEvsuuT7tnlweOw967f6tL5xU8vwBTrYljMcmG-p_rFArO-B8bm4vq</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>SIMONFAU-ROY, J</creator><creator>MARTI, S</creator><creator>DEAL, C</creator><creator>HUOT, C</creator><creator>ROBAEY, P</creator><creator>VAN VLIET, Guy</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine</title><author>SIMONFAU-ROY, J ; MARTI, S ; DEAL, C ; HUOT, C ; ROBAEY, P ; VAN VLIET, Guy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1821-a4c6306dd215c133575844a5316b1f1315167065f90608957b2f424b9ebc7da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child Behavior Disorders - epidemiology</topic><topic>Child Behavior Disorders - prevention & control</topic><topic>Child, Preschool</topic><topic>Cognition - drug effects</topic><topic>Congenital Hypothyroidism</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Developmental Disabilities - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hypothyroidism - drug therapy</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Prospective Studies</topic><topic>Quebec - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroxine - administration & dosage</topic><topic>Thyroxine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SIMONFAU-ROY, J</creatorcontrib><creatorcontrib>MARTI, S</creatorcontrib><creatorcontrib>DEAL, C</creatorcontrib><creatorcontrib>HUOT, C</creatorcontrib><creatorcontrib>ROBAEY, P</creatorcontrib><creatorcontrib>VAN VLIET, Guy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SIMONFAU-ROY, J</au><au>MARTI, S</au><au>DEAL, C</au><au>HUOT, C</au><au>ROBAEY, P</au><au>VAN VLIET, Guy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2004-06</date><risdate>2004</risdate><volume>144</volume><issue>6</issue><spage>747</spage><epage>752</epage><pages>747-752</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per day of levothyroxine were evaluated at 5 years, 9 months, with the McCarthy Scale and the Questionnaire for Evaluation of Social Behavior, as were 40 control children.
The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P=.02) and inattention (P=.05), whereas the number of times TSH was <0.8 mIU/L was correlated with lower verbal scores (P=.05).
Children with severe CH treated early with a high dose of levothyroxine have normal global development and behavior at school entry.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>15192621</pmid><doi>10.1016/S0022-3476(04)00142-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis of Variance Biological and medical sciences Child Behavior Disorders - epidemiology Child Behavior Disorders - prevention & control Child, Preschool Cognition - drug effects Congenital Hypothyroidism Developmental Disabilities - epidemiology Developmental Disabilities - prevention & control Dose-Response Relationship, Drug Endocrinopathies Female General aspects Humans Hypothyroidism - drug therapy Infant, Newborn Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Prospective Studies Quebec - epidemiology Severity of Illness Index Statistics, Nonparametric Thyroid. Thyroid axis (diseases) Thyroxine - administration & dosage Thyroxine - pharmacology |
| title | Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine |
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