Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus

Prior research has revealed that treatments that elevate the level of the pro-inflammatory cytokine IL-1β in the brain, if given after training, impair contextual but not auditory-cue fear conditioning. The present experiments add to these finding by showing that, (a) IL-1β exerts its effect on cont...

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Veröffentlicht in:	Behavioural brain research 2002-08, Vol.134 (1), p.291-298
Hauptverfasser:	Barrientos, Ruth M, Higgins, Emily A, Sprunger, David B, Watkins, Linda R, Rudy, Jerry W, Maier, Steven F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animals Biological and medical sciences Consolidation timecourse Contextual fear conditioning Corticosterone Corticosterone - blood Fear - psychology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Humans Injections, Intraventricular Interleukin-1 - administration & dosage Interleukin-1 - pharmacology Interleukin-1 beta Learning. Memory Long-Term Potentiation - drug effects Male Memory Memory - drug effects Microinjections Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology
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