Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma
Patients with unresectable, stage I and II perihilar cholangiocarcinoma were treated with neoadjuvant external beam irradiation, brachytherapy, and 5-fluorouracil and/or oral capecitabine prior to liver transplantation. Fifty-six patients underwent treatment between 1993 and 2003. Four patients died...
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| Veröffentlicht in: | Seminars in liver disease 2004-05, Vol.24 (2), p.201-207 |
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| container_title | Seminars in liver disease |
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| creator | Heimbach, Julie K Gores, Gregory J Haddock, Michael G Alberts, Steven R Nyberg, Scott L Ishitani, Michael B Rosen, Charles B |
| description | Patients with unresectable, stage I and II perihilar cholangiocarcinoma were treated with neoadjuvant external beam irradiation, brachytherapy, and 5-fluorouracil and/or oral capecitabine prior to liver transplantation. Fifty-six patients underwent treatment between 1993 and 2003. Four patients died and 4 had disease progression prior to completion of neoadjuvant therapy. Forty-eight patients underwent operative staging and 14 had findings precluding transplantation. Twenty-eight patients underwent transplantation and 6 patients are awaiting transplantation. Three patients died from perioperative complications, and 4 developed recurrent disease 22 to 63 months after transplantation. Actuarial patient survival was 54% at 5 years for all 56 patients, 64% for 48 operatively staged patients, and 84% for 34 patients with negative staging operations. Actuarial survival was 88% at 1 year and 82 % 5 years after transplantation. Neoadjuvant chemoradiotherapy with liver transplantation achieves excellent results for patients with localized, regional lymph node negative, hilar cholangiocarcinoma. |
| doi_str_mv | 10.1055/s-2004-828896 |
| format | Article |
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Fifty-six patients underwent treatment between 1993 and 2003. Four patients died and 4 had disease progression prior to completion of neoadjuvant therapy. Forty-eight patients underwent operative staging and 14 had findings precluding transplantation. Twenty-eight patients underwent transplantation and 6 patients are awaiting transplantation. Three patients died from perioperative complications, and 4 developed recurrent disease 22 to 63 months after transplantation. Actuarial patient survival was 54% at 5 years for all 56 patients, 64% for 48 operatively staged patients, and 84% for 34 patients with negative staging operations. Actuarial survival was 88% at 1 year and 82 % 5 years after transplantation. 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Fifty-six patients underwent treatment between 1993 and 2003. Four patients died and 4 had disease progression prior to completion of neoadjuvant therapy. Forty-eight patients underwent operative staging and 14 had findings precluding transplantation. Twenty-eight patients underwent transplantation and 6 patients are awaiting transplantation. Three patients died from perioperative complications, and 4 developed recurrent disease 22 to 63 months after transplantation. Actuarial patient survival was 54% at 5 years for all 56 patients, 64% for 48 operatively staged patients, and 84% for 34 patients with negative staging operations. Actuarial survival was 88% at 1 year and 82 % 5 years after transplantation. Neoadjuvant chemoradiotherapy with liver transplantation achieves excellent results for patients with localized, regional lymph node negative, hilar cholangiocarcinoma.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - radiotherapy</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Brachytherapy</subject><subject>Cholangiocarcinoma - mortality</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - radiotherapy</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0272-8087</issn><issn>1098-8971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqUwsqJMTAT8iGN7RBUvqRIM7Ww59g11lcTFTpD496RKJSamuxwdffcgdE3wPcGcP6ScYlzkkkqpyhM0J1jJXCpBTtEcU0FziaWYoYuUdhhjqgp8jmaEE0WFonO0XPlviNk6mi7tG9P1pvehy-oQs00XIYHtTdVA9gHRb31jYrbchpH79MGaaH0XWnOJzmrTJLg63gXaPD-tl6_56v3lbfm4yi2jZZ-z2ipR1lzxqnCVwbXDFSOS1QScMM7VJWEFcEyZABDUOWXHtdxxyS0ri4ot0O3k3cfwNUDqdeuThWacA2FIWlBMGBflCOYTaGNIKUKt99G3Jv5ogvWhmk76UE1P1Ub-5igeqhbcH33MNAJ3E9BvPbSgd2GI3fjqP75f3lB2SA</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Heimbach, Julie K</creator><creator>Gores, Gregory J</creator><creator>Haddock, Michael G</creator><creator>Alberts, Steven R</creator><creator>Nyberg, Scott L</creator><creator>Ishitani, Michael B</creator><creator>Rosen, Charles B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma</title><author>Heimbach, Julie K ; 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| identifier | ISSN: 0272-8087 |
| ispartof | Seminars in liver disease, 2004-05, Vol.24 (2), p.201-207 |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - radiotherapy Bile Duct Neoplasms - surgery Brachytherapy Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Cholangiocarcinoma - radiotherapy Cholangiocarcinoma - surgery Female Humans Liver Transplantation Male Middle Aged Neoadjuvant Therapy Survival Rate Treatment Outcome |
| title | Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma |
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