Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection

Summary The tprK gene sequence of Treponema pallidum subspecies pallidum (T. pallidum) is heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is localized in seven discrete variable (V) regions, and variability results from apparent base changes, insertions or delet...

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Veröffentlicht in:	Molecular microbiology 2004-06, Vol.52 (6), p.1579-1596
Hauptverfasser:	Centurion‐Lara, Arturo, LaFond, Rebecca E., Hevner, Karin, Godornes, Charmie, Molini, Barbara J., Van Voorhis, Wesley C., Lukehart, Sheila A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigenic Variation Antigens, Surface - genetics Antigens, Surface - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology Bacteriology Base Sequence Biological and medical sciences DNA, Bacterial - chemistry DNA, Bacterial - isolation & purification Fundamental and applied biological sciences. Psychology Gene Conversion Genes, Bacterial Genetic Variation Male Microbiology Miscellaneous Molecular Sequence Data Porins - genetics Porins - immunology Rabbits Sequence Analysis, DNA Syphilis - microbiology Testis - microbiology Treponema pallidum Treponema pallidum - genetics Treponema pallidum - growth & development Treponema pallidum - pathogenicity
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