NKG2D blockade prevents autoimmune diabetes in NOD mice
NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Trea...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2004-06, Vol.20 (6), p.757-767 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Ogasawara, Kouetsu Hamerman, Jessica A Ehrlich, Lauren R Bour-Jordan, Helene Santamaria, Pere Bluestone, Jeffrey A Lanier, Lewis L |
| description | NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8(+) T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes. |
| doi_str_mv | 10.1016/j.immuni.2004.05.008 |
| format | Article |
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Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8(+) T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2004.05.008</identifier><identifier>PMID: 15189740</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adoptive Transfer ; Animals ; Antibodies - immunology ; Antibodies - pharmacology ; Antibodies - therapeutic use ; Autoimmune diseases ; CD8-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cell Division ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - immunology ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - prevention & control ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - prevention & control ; Flow Cytometry ; Insulin ; Islets of Langerhans - cytology ; Islets of Langerhans - drug effects ; Islets of Langerhans - metabolism ; Medical research ; Membrane Proteins - genetics ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mice, Transgenic ; NK Cell Lectin-Like Receptor Subfamily K ; Pancreas ; Receptors, Immunologic - antagonists & inhibitors ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism ; Receptors, Natural Killer Cell ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents</subject><ispartof>Immunity (Cambridge, Mass.), 2004-06, Vol.20 (6), p.757-767</ispartof><rights>Copyright Elsevier Limited Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-2d20dff13f9cd396b92f4e0c74eaf47192c4eb6ed3936043ab73bf5a45be96593</citedby><cites>FETCH-LOGICAL-c408t-2d20dff13f9cd396b92f4e0c74eaf47192c4eb6ed3936043ab73bf5a45be96593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15189740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogasawara, Kouetsu</creatorcontrib><creatorcontrib>Hamerman, Jessica A</creatorcontrib><creatorcontrib>Ehrlich, Lauren R</creatorcontrib><creatorcontrib>Bour-Jordan, Helene</creatorcontrib><creatorcontrib>Santamaria, Pere</creatorcontrib><creatorcontrib>Bluestone, Jeffrey A</creatorcontrib><creatorcontrib>Lanier, Lewis L</creatorcontrib><title>NKG2D blockade prevents autoimmune diabetes in NOD mice</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. 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These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Antibodies - pharmacology</subject><subject>Antibodies - therapeutic use</subject><subject>Autoimmune diseases</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cell Division</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 1 - prevention & control</subject><subject>Flow Cytometry</subject><subject>Insulin</subject><subject>Islets of Langerhans - cytology</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - metabolism</subject><subject>Medical research</subject><subject>Membrane Proteins - genetics</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Mice, Transgenic</subject><subject>NK Cell Lectin-Like Receptor Subfamily K</subject><subject>Pancreas</subject><subject>Receptors, Immunologic - antagonists & inhibitors</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Natural Killer Cell</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-A5GA4C1x9jt7FKtVLO1Fz8smmUBiPmo2Efz3JrYgePE0A_O8M8xDyCWFiAJVt2VU1PXQFBEDEBHICCA-InMKRoeCxnA89VqEWlE-I2felwBUSAOnZEYljY0WMCd687JiyyCp2vTdZRjsOvzEpveBG_r25wAGWeES7NEHRRNstsugLlI8Jye5qzxeHOqCvD0-vN4_hevt6vn-bh2mAuI-ZBmDLM8pz02acaMSw3KBkGqBLheaGpYKTBSOM65AcJdonuTSCZmgUdLwBbnZ79117ceAvrd14VOsKtdgO3irGVBmFPwLUm2MEmICr_-AZTt0zfiEpRIEY4qDHCmxp9Ku9b7D3O66onbdl6VgJ_-2tHv_dvJvQdrR_xi7Oiwfkhqz39BBOP8GsYWAwQ</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Ogasawara, Kouetsu</creator><creator>Hamerman, Jessica A</creator><creator>Ehrlich, Lauren R</creator><creator>Bour-Jordan, Helene</creator><creator>Santamaria, Pere</creator><creator>Bluestone, Jeffrey A</creator><creator>Lanier, Lewis L</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>NKG2D blockade prevents autoimmune diabetes in NOD mice</title><author>Ogasawara, Kouetsu ; 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| subjects | Adoptive Transfer Animals Antibodies - immunology Antibodies - pharmacology Antibodies - therapeutic use Autoimmune diseases CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Division Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - prevention & control Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - prevention & control Flow Cytometry Insulin Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Medical research Membrane Proteins - genetics Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic NK Cell Lectin-Like Receptor Subfamily K Pancreas Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, Natural Killer Cell RNA, Messenger - genetics RNA, Messenger - metabolism Rodents |
| title | NKG2D blockade prevents autoimmune diabetes in NOD mice |
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