Localised Extranodal Lymphoma of the Head and Neck: The Sheffield Lymphoma Group Experience (1971–2000)
Aims: Over the 30-year period from 1971–2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database revie...
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Veröffentlicht in: | Clinical oncology (Royal College of Radiologists (Great Britain)) 2004-05, Vol.16 (3), p.186-192 |
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creator | Hart, S. Horsman, J.M. Radstone, C.R. Hancock, H. Goepel, J.R. Hancock, B.W. |
description | Aims: Over the 30-year period from 1971–2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
Materials and methods: The sample included 98 women and 92 men, with a median age at presentation of 65 years.
Results: The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47–62) and 44% (95% CI 36–53), respectively, with a median survival of 92 months (95% CI 56–128). Stage and grade were both found to influence survival.
Conclusion: This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites. |
doi_str_mv | 10.1016/j.clon.2003.10.010 |
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Materials and methods: The sample included 98 women and 92 men, with a median age at presentation of 65 years.
Results: The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47–62) and 44% (95% CI 36–53), respectively, with a median survival of 92 months (95% CI 56–128). Stage and grade were both found to influence survival.
Conclusion: This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.</description><identifier>ISSN: 0936-6555</identifier><identifier>EISSN: 1433-2981</identifier><identifier>DOI: 10.1016/j.clon.2003.10.010</identifier><identifier>PMID: 15191005</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Databases, Factual ; Female ; Head and neck ; Head and Neck Neoplasms - pathology ; Humans ; Lymphoma, Non-Hodgkin - pathology ; Male ; Middle Aged ; Neoplasm Staging ; non-Hodgkin's lymphoma ; Prognosis ; Retrospective Studies ; Survival Analysis</subject><ispartof>Clinical oncology (Royal College of Radiologists (Great Britain)), 2004-05, Vol.16 (3), p.186-192</ispartof><rights>2004 The Royal College of Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-4e86e8b57a3e671a827d97011ea61f236e1a1a813d7e0af0cb526194e28b075b3</citedby><cites>FETCH-LOGICAL-c352t-4e86e8b57a3e671a827d97011ea61f236e1a1a813d7e0af0cb526194e28b075b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clon.2003.10.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15191005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hart, S.</creatorcontrib><creatorcontrib>Horsman, J.M.</creatorcontrib><creatorcontrib>Radstone, C.R.</creatorcontrib><creatorcontrib>Hancock, H.</creatorcontrib><creatorcontrib>Goepel, J.R.</creatorcontrib><creatorcontrib>Hancock, B.W.</creatorcontrib><title>Localised Extranodal Lymphoma of the Head and Neck: The Sheffield Lymphoma Group Experience (1971–2000)</title><title>Clinical oncology (Royal College of Radiologists (Great Britain))</title><addtitle>Clin Oncol (R Coll Radiol)</addtitle><description>Aims: Over the 30-year period from 1971–2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
Materials and methods: The sample included 98 women and 92 men, with a median age at presentation of 65 years.
Results: The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47–62) and 44% (95% CI 36–53), respectively, with a median survival of 92 months (95% CI 56–128). Stage and grade were both found to influence survival.
Conclusion: This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Head and neck</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>non-Hodgkin's lymphoma</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><issn>0936-6555</issn><issn>1433-2981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtuFDEQRS1ERIbAD7BAXiFY9KTKHvcDsUFRXtIoLAhry21Xazx0txu7B5Ed_8Af8iXxMCNlx6qkq1NXVYexNwhLBCzPt0vbh3EpAGQOloDwjC1wJWUhmhqfswU0sixKpdQpe5nSFgBEXTcv2CkqbBBALZhfB2t6n8jxy19zNGNwpufrh2HahMHw0PF5Q_yGjONmdPyO7PeP_D5HXzfUdZ569wRfx7Cbcs1E0dNoib_HpsK_v__kC-HDK3bSmT7R6-M8Y9-uLu8vbor1l-vbi8_rwkol5mJFdUl1qyojqazQ1KJyTQWIZErshCwJTU5RuorAdGBbJUpsViTqFirVyjP27tA7xfBjR2nWg0-W-t6MFHZJVwJQNAozKA6gjSGlSJ2eoh9MfNAIei9Yb_VesN4L3mdZcF56e2zftQO5p5Wj0Qx8OgCUf_zpKepk_9lwPpKdtQv-f_2PvCiKpg</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Hart, S.</creator><creator>Horsman, J.M.</creator><creator>Radstone, C.R.</creator><creator>Hancock, H.</creator><creator>Goepel, J.R.</creator><creator>Hancock, B.W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Localised Extranodal Lymphoma of the Head and Neck: The Sheffield Lymphoma Group Experience (1971–2000)</title><author>Hart, S. ; Horsman, J.M. ; Radstone, C.R. ; Hancock, H. ; Goepel, J.R. ; Hancock, B.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-4e86e8b57a3e671a827d97011ea61f236e1a1a813d7e0af0cb526194e28b075b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Head and neck</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>non-Hodgkin's lymphoma</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hart, S.</creatorcontrib><creatorcontrib>Horsman, J.M.</creatorcontrib><creatorcontrib>Radstone, C.R.</creatorcontrib><creatorcontrib>Hancock, H.</creatorcontrib><creatorcontrib>Goepel, J.R.</creatorcontrib><creatorcontrib>Hancock, B.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oncology (Royal College of Radiologists (Great Britain))</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hart, S.</au><au>Horsman, J.M.</au><au>Radstone, C.R.</au><au>Hancock, H.</au><au>Goepel, J.R.</au><au>Hancock, B.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localised Extranodal Lymphoma of the Head and Neck: The Sheffield Lymphoma Group Experience (1971–2000)</atitle><jtitle>Clinical oncology (Royal College of Radiologists (Great Britain))</jtitle><addtitle>Clin Oncol (R Coll Radiol)</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>16</volume><issue>3</issue><spage>186</spage><epage>192</epage><pages>186-192</pages><issn>0936-6555</issn><eissn>1433-2981</eissn><abstract>Aims: Over the 30-year period from 1971–2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
Materials and methods: The sample included 98 women and 92 men, with a median age at presentation of 65 years.
Results: The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47–62) and 44% (95% CI 36–53), respectively, with a median survival of 92 months (95% CI 56–128). Stage and grade were both found to influence survival.
Conclusion: This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15191005</pmid><doi>10.1016/j.clon.2003.10.010</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Databases, Factual Female Head and neck Head and Neck Neoplasms - pathology Humans Lymphoma, Non-Hodgkin - pathology Male Middle Aged Neoplasm Staging non-Hodgkin's lymphoma Prognosis Retrospective Studies Survival Analysis |
title | Localised Extranodal Lymphoma of the Head and Neck: The Sheffield Lymphoma Group Experience (1971–2000) |
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