Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI
Developments in MRI have made it possible to use diffusion-weighted MRI, perfusion MRI and proton MR spectroscopy (MRS) to study lesions in the brain. We evaluated whether these techniques provide useful, complementary information for grading gliomas, in comparison with conventional MRI. We studied...
Gespeichert in:
Veröffentlicht in: | Neuroradiology 2002-08, Vol.44 (8), p.656-666 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 666 |
---|---|
container_issue | 8 |
container_start_page | 656 |
container_title | Neuroradiology |
container_volume | 44 |
creator | YANG, D KOROGI, Y SUGAHARA, T KITAJIMA, M SHIGEMATSU, Y LIANG, L USHIO, Y TAKAHASHI, M |
description | Developments in MRI have made it possible to use diffusion-weighted MRI, perfusion MRI and proton MR spectroscopy (MRS) to study lesions in the brain. We evaluated whether these techniques provide useful, complementary information for grading gliomas, in comparison with conventional MRI. We studied 17 patients with histologically verified gliomas, adding multivoxel proton MRS, echoplanar diffusion and perfusion MRI the a routine MRI examination. The maximum relative cerebral blood volume (CBV), minimum apparent diffusion coefficient (ADC) and metabolic peak area ratios in proton MRS were calculated in solid parts of tumours on the same slice from each imaging data set. The mean minimum ADC of the 13 high-grade gliomas (0.92+/-0.27 x 10(-3) mm(2)/s) was lower than that of the four low-grade gliomas (1.28+/-0.15 x 10(-3) mm(2)/s) ( P |
doi_str_mv | 10.1007/s00234-002-0816-9 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72012641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>692023871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-f2e32abe938de3f210eff13bf1aa080f0f33983c6564f573b9ab6539a7614f093</originalsourceid><addsrcrecordid>eNpdkd1u1DAQhS1ERbeFB-AGWUj0CpexnT_3Di1_lYqQEFxbjjPedZXEwU6AvkkfF4ddqVJvxvL4m6PjOYS85HDJAep3CUDIguXKoOEVU0_IhhdSMK4EPCWb_NAwqQo4JWcp3QKArGX9jJxywZuyLOSG3G8xYhtNT3e9D4NJV3SKIU1oZ_8bqQ3DZKJPYaTB0WHpczf8xZ6KD9TucfDW9CztvZupH8zOj7t1fM741-_0v0oWs2G6e0vR7sPUm9FEOmF0S_KZMmNHO-8ON_YH_W4_Y5eHr5-TE2f6hC-O5zn5-enjj-0XdvPt8_X2_Q2zhYCZOYFSmBaVbDqUTnBA57hsHTcGGnDgpFSNtFVZFa6sZatMW5VSmbrihQMlz8nFQTf7_rVgmvXgk8U-O8WwJF0L4KIqeAZfPwJvwxLH7E0LwYVQVQ0Z4gfI5n-niE5PMS8m3mkOes1MHzLTueo1M706eHUUXtoBu4eJY0gZeHMETMr7dtGM1qcHTq5Y3ch_cDqhOA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221229670</pqid></control><display><type>article</type><title>Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>YANG, D ; KOROGI, Y ; SUGAHARA, T ; KITAJIMA, M ; SHIGEMATSU, Y ; LIANG, L ; USHIO, Y ; TAKAHASHI, M</creator><creatorcontrib>YANG, D ; KOROGI, Y ; SUGAHARA, T ; KITAJIMA, M ; SHIGEMATSU, Y ; LIANG, L ; USHIO, Y ; TAKAHASHI, M</creatorcontrib><description>Developments in MRI have made it possible to use diffusion-weighted MRI, perfusion MRI and proton MR spectroscopy (MRS) to study lesions in the brain. We evaluated whether these techniques provide useful, complementary information for grading gliomas, in comparison with conventional MRI. We studied 17 patients with histologically verified gliomas, adding multivoxel proton MRS, echoplanar diffusion and perfusion MRI the a routine MRI examination. The maximum relative cerebral blood volume (CBV), minimum apparent diffusion coefficient (ADC) and metabolic peak area ratios in proton MRS were calculated in solid parts of tumours on the same slice from each imaging data set. The mean minimum ADC of the 13 high-grade gliomas (0.92+/-0.27 x 10(-3) mm(2)/s) was lower than that of the four low-grade gliomas (1.28+/-0.15 x 10(-3) mm(2)/s) ( P<0.05). Means of maximum choline (Cho)/N-acetylaspartate (NAA), Cho/creatine (Cr), Cho/Cr in normal brain (Cr-n) and minimum NAA/Cr ratios were 5.90+/-2.62, 4.73+/-2.22, 2.66+/-0.68 and 0.40+/-0.06, respectively, in the high-grade gliomas, and 1.65+/-1.37, 1.84+/-1.20, 1.61+/-1.29 and 1.65+/-1.61, respectively, in the low-grade gliomas. Significant differences were found on spectroscopy between the high- and low-grade gliomas ( P<0.05). Mean maximum relative CBV in the high-grade gliomas (6.10+/-3.98) was higher than in the low-grade gliomas (1.74+/-0.57) ( P<0.05). Echoplanar diffusion, perfusion MRI and multivoxel proton MRS can offer diagnostic information, not available with conventional MRI, in the assessment of glioma grade.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-002-0816-9</identifier><identifier>PMID: 12185543</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Brain - pathology ; Echo-Planar Imaging ; Female ; Glioma - diagnosis ; Glioma - pathology ; Humans ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Middle Aged ; Neurology ; Prospective Studies ; Supratentorial Neoplasms - diagnosis ; Supratentorial Neoplasms - pathology ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Neuroradiology, 2002-08, Vol.44 (8), p.656-666</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Springer-Verlag New York, Inc. Aug 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f2e32abe938de3f210eff13bf1aa080f0f33983c6564f573b9ab6539a7614f093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13855478$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12185543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YANG, D</creatorcontrib><creatorcontrib>KOROGI, Y</creatorcontrib><creatorcontrib>SUGAHARA, T</creatorcontrib><creatorcontrib>KITAJIMA, M</creatorcontrib><creatorcontrib>SHIGEMATSU, Y</creatorcontrib><creatorcontrib>LIANG, L</creatorcontrib><creatorcontrib>USHIO, Y</creatorcontrib><creatorcontrib>TAKAHASHI, M</creatorcontrib><title>Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description>Developments in MRI have made it possible to use diffusion-weighted MRI, perfusion MRI and proton MR spectroscopy (MRS) to study lesions in the brain. We evaluated whether these techniques provide useful, complementary information for grading gliomas, in comparison with conventional MRI. We studied 17 patients with histologically verified gliomas, adding multivoxel proton MRS, echoplanar diffusion and perfusion MRI the a routine MRI examination. The maximum relative cerebral blood volume (CBV), minimum apparent diffusion coefficient (ADC) and metabolic peak area ratios in proton MRS were calculated in solid parts of tumours on the same slice from each imaging data set. The mean minimum ADC of the 13 high-grade gliomas (0.92+/-0.27 x 10(-3) mm(2)/s) was lower than that of the four low-grade gliomas (1.28+/-0.15 x 10(-3) mm(2)/s) ( P<0.05). Means of maximum choline (Cho)/N-acetylaspartate (NAA), Cho/creatine (Cr), Cho/Cr in normal brain (Cr-n) and minimum NAA/Cr ratios were 5.90+/-2.62, 4.73+/-2.22, 2.66+/-0.68 and 0.40+/-0.06, respectively, in the high-grade gliomas, and 1.65+/-1.37, 1.84+/-1.20, 1.61+/-1.29 and 1.65+/-1.61, respectively, in the low-grade gliomas. Significant differences were found on spectroscopy between the high- and low-grade gliomas ( P<0.05). Mean maximum relative CBV in the high-grade gliomas (6.10+/-3.98) was higher than in the low-grade gliomas (1.74+/-0.57) ( P<0.05). Echoplanar diffusion, perfusion MRI and multivoxel proton MRS can offer diagnostic information, not available with conventional MRI, in the assessment of glioma grade.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Echo-Planar Imaging</subject><subject>Female</subject><subject>Glioma - diagnosis</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Supratentorial Neoplasms - diagnosis</subject><subject>Supratentorial Neoplasms - pathology</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkd1u1DAQhS1ERbeFB-AGWUj0CpexnT_3Di1_lYqQEFxbjjPedZXEwU6AvkkfF4ddqVJvxvL4m6PjOYS85HDJAep3CUDIguXKoOEVU0_IhhdSMK4EPCWb_NAwqQo4JWcp3QKArGX9jJxywZuyLOSG3G8xYhtNT3e9D4NJV3SKIU1oZ_8bqQ3DZKJPYaTB0WHpczf8xZ6KD9TucfDW9CztvZupH8zOj7t1fM741-_0v0oWs2G6e0vR7sPUm9FEOmF0S_KZMmNHO-8ON_YH_W4_Y5eHr5-TE2f6hC-O5zn5-enjj-0XdvPt8_X2_Q2zhYCZOYFSmBaVbDqUTnBA57hsHTcGGnDgpFSNtFVZFa6sZatMW5VSmbrihQMlz8nFQTf7_rVgmvXgk8U-O8WwJF0L4KIqeAZfPwJvwxLH7E0LwYVQVQ0Z4gfI5n-niE5PMS8m3mkOes1MHzLTueo1M706eHUUXtoBu4eJY0gZeHMETMr7dtGM1qcHTq5Y3ch_cDqhOA</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>YANG, D</creator><creator>KOROGI, Y</creator><creator>SUGAHARA, T</creator><creator>KITAJIMA, M</creator><creator>SHIGEMATSU, Y</creator><creator>LIANG, L</creator><creator>USHIO, Y</creator><creator>TAKAHASHI, M</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI</title><author>YANG, D ; KOROGI, Y ; SUGAHARA, T ; KITAJIMA, M ; SHIGEMATSU, Y ; LIANG, L ; USHIO, Y ; TAKAHASHI, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f2e32abe938de3f210eff13bf1aa080f0f33983c6564f573b9ab6539a7614f093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Echo-Planar Imaging</topic><topic>Female</topic><topic>Glioma - diagnosis</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Supratentorial Neoplasms - diagnosis</topic><topic>Supratentorial Neoplasms - pathology</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YANG, D</creatorcontrib><creatorcontrib>KOROGI, Y</creatorcontrib><creatorcontrib>SUGAHARA, T</creatorcontrib><creatorcontrib>KITAJIMA, M</creatorcontrib><creatorcontrib>SHIGEMATSU, Y</creatorcontrib><creatorcontrib>LIANG, L</creatorcontrib><creatorcontrib>USHIO, Y</creatorcontrib><creatorcontrib>TAKAHASHI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YANG, D</au><au>KOROGI, Y</au><au>SUGAHARA, T</au><au>KITAJIMA, M</au><au>SHIGEMATSU, Y</au><au>LIANG, L</au><au>USHIO, Y</au><au>TAKAHASHI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI</atitle><jtitle>Neuroradiology</jtitle><addtitle>Neuroradiology</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>44</volume><issue>8</issue><spage>656</spage><epage>666</epage><pages>656-666</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract>Developments in MRI have made it possible to use diffusion-weighted MRI, perfusion MRI and proton MR spectroscopy (MRS) to study lesions in the brain. We evaluated whether these techniques provide useful, complementary information for grading gliomas, in comparison with conventional MRI. We studied 17 patients with histologically verified gliomas, adding multivoxel proton MRS, echoplanar diffusion and perfusion MRI the a routine MRI examination. The maximum relative cerebral blood volume (CBV), minimum apparent diffusion coefficient (ADC) and metabolic peak area ratios in proton MRS were calculated in solid parts of tumours on the same slice from each imaging data set. The mean minimum ADC of the 13 high-grade gliomas (0.92+/-0.27 x 10(-3) mm(2)/s) was lower than that of the four low-grade gliomas (1.28+/-0.15 x 10(-3) mm(2)/s) ( P<0.05). Means of maximum choline (Cho)/N-acetylaspartate (NAA), Cho/creatine (Cr), Cho/Cr in normal brain (Cr-n) and minimum NAA/Cr ratios were 5.90+/-2.62, 4.73+/-2.22, 2.66+/-0.68 and 0.40+/-0.06, respectively, in the high-grade gliomas, and 1.65+/-1.37, 1.84+/-1.20, 1.61+/-1.29 and 1.65+/-1.61, respectively, in the low-grade gliomas. Significant differences were found on spectroscopy between the high- and low-grade gliomas ( P<0.05). Mean maximum relative CBV in the high-grade gliomas (6.10+/-3.98) was higher than in the low-grade gliomas (1.74+/-0.57) ( P<0.05). Echoplanar diffusion, perfusion MRI and multivoxel proton MRS can offer diagnostic information, not available with conventional MRI, in the assessment of glioma grade.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12185543</pmid><doi>10.1007/s00234-002-0816-9</doi><tpages>11</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0028-3940 |
ispartof | Neuroradiology, 2002-08, Vol.44 (8), p.656-666 |
issn | 0028-3940 1432-1920 |
language | eng |
recordid | cdi_proquest_miscellaneous_72012641 |
source | MEDLINE; SpringerNature Journals |
subjects | Adolescent Adult Aged Biological and medical sciences Brain - pathology Echo-Planar Imaging Female Glioma - diagnosis Glioma - pathology Humans Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Neurology Prospective Studies Supratentorial Neoplasms - diagnosis Supratentorial Neoplasms - pathology Tumors of the nervous system. Phacomatoses |
title | Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T06%3A25%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20gliomas:%20prospective%20comparison%20of%20multivoxel%202D%20chemical-shift%20imaging%20proton%20MR%20spectroscopy,%20echoplanar%20perfusion%20and%20diffusion-weighted%20MRI&rft.jtitle=Neuroradiology&rft.au=YANG,%20D&rft.date=2002-08-01&rft.volume=44&rft.issue=8&rft.spage=656&rft.epage=666&rft.pages=656-666&rft.issn=0028-3940&rft.eissn=1432-1920&rft.coden=NRDYAB&rft_id=info:doi/10.1007/s00234-002-0816-9&rft_dat=%3Cproquest_cross%3E692023871%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=221229670&rft_id=info:pmid/12185543&rfr_iscdi=true |