Chemokines: directing leukocyte infiltration into allografts
Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemok...
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| Veröffentlicht in: | Current Opinion in Immunology 2002-10, Vol.14 (5), p.562-568 |
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| container_title | Current Opinion in Immunology |
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| creator | El-Sawy, Tarek Fahmy, Nader M Fairchild, Robert L |
| description | Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemokines or chemokine receptors has been shown to delay leukocyte infiltration and prolong graft function, demonstrating an important role for chemokines in allograft rejection.
The chemokine system plays an important role directing leukocyte recruitment into transplanted organs and its anatagonism may provide a novel therapeutic target to improve clinical outcomes. |
| doi_str_mv | 10.1016/S0952-7915(02)00382-5 |
| format | Article |
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The chemokine system plays an important role directing leukocyte recruitment into transplanted organs and its anatagonism may provide a novel therapeutic target to improve clinical outcomes.</description><identifier>ISSN: 0952-7915</identifier><identifier>EISSN: 1879-0372</identifier><identifier>DOI: 10.1016/S0952-7915(02)00382-5</identifier><identifier>PMID: 12183154</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>allograft infiltration ; Animals ; chemokine receptors ; chemokines ; Chemokines - physiology ; Graft Rejection - immunology ; Humans ; inflammation ; ischemia/reperfusion ; Leukocytes - physiology ; Receptors, Chemokine - physiology ; Transplantation ; Transplantation, Homologous - immunology</subject><ispartof>Current Opinion in Immunology, 2002-10, Vol.14 (5), p.562-568</ispartof><rights>2002 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-8aa8ad5971b51249fa66aa70f58716590ee078dce6adb5c793868c7eafc9389b3</citedby><cites>FETCH-LOGICAL-c392t-8aa8ad5971b51249fa66aa70f58716590ee078dce6adb5c793868c7eafc9389b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0952-7915(02)00382-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3550,27922,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12183154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Sawy, Tarek</creatorcontrib><creatorcontrib>Fahmy, Nader M</creatorcontrib><creatorcontrib>Fairchild, Robert L</creatorcontrib><title>Chemokines: directing leukocyte infiltration into allografts</title><title>Current Opinion in Immunology</title><addtitle>Curr Opin Immunol</addtitle><description>Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemokines or chemokine receptors has been shown to delay leukocyte infiltration and prolong graft function, demonstrating an important role for chemokines in allograft rejection.
The chemokine system plays an important role directing leukocyte recruitment into transplanted organs and its anatagonism may provide a novel therapeutic target to improve clinical outcomes.</description><subject>allograft infiltration</subject><subject>Animals</subject><subject>chemokine receptors</subject><subject>chemokines</subject><subject>Chemokines - physiology</subject><subject>Graft Rejection - immunology</subject><subject>Humans</subject><subject>inflammation</subject><subject>ischemia/reperfusion</subject><subject>Leukocytes - physiology</subject><subject>Receptors, Chemokine - physiology</subject><subject>Transplantation</subject><subject>Transplantation, Homologous - immunology</subject><issn>0952-7915</issn><issn>1879-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_grIn0cPqJNtsEhFEil9Q8KCeQzY7W2O3m5pshf57tx_osaeZgeedFx5CTilcUaD59RsozlKhKL8AdgmQSZbyPdKnUqgUMsH2Sf8P6ZGjGL8AgPMMDkmPMiozyod9cjv6xJmfugbjTVK6gLZ1zSSpcTH1dtli4prK1W0wrfNNd7Q-MXXtJ8FUbTwmB5WpI55s54B8PD68j57T8evTy-h-nNpMsTaVxkhTciVowSkbqsrkuTECKi4FzbkCRBCytJibsuBWqEzm0go0le1WVWQDcr75Ow_-e4Gx1TMXLda1adAvohYMKGM82wlSyZWignYg34A2-BgDVnoe3MyEpaagV3712q9eydPA9Nqv5l3ubFuwKGZY_qe2QjvgbgNg5-PHYdDROmwsbtzq0rsdFb-21opU</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>El-Sawy, Tarek</creator><creator>Fahmy, Nader M</creator><creator>Fairchild, Robert L</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Chemokines: directing leukocyte infiltration into allografts</title><author>El-Sawy, Tarek ; Fahmy, Nader M ; Fairchild, Robert L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-8aa8ad5971b51249fa66aa70f58716590ee078dce6adb5c793868c7eafc9389b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>allograft infiltration</topic><topic>Animals</topic><topic>chemokine receptors</topic><topic>chemokines</topic><topic>Chemokines - physiology</topic><topic>Graft Rejection - immunology</topic><topic>Humans</topic><topic>inflammation</topic><topic>ischemia/reperfusion</topic><topic>Leukocytes - physiology</topic><topic>Receptors, Chemokine - physiology</topic><topic>Transplantation</topic><topic>Transplantation, Homologous - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Sawy, Tarek</creatorcontrib><creatorcontrib>Fahmy, Nader M</creatorcontrib><creatorcontrib>Fairchild, Robert L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Sawy, Tarek</au><au>Fahmy, Nader M</au><au>Fairchild, Robert L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemokines: directing leukocyte infiltration into allografts</atitle><jtitle>Current Opinion in Immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>14</volume><issue>5</issue><spage>562</spage><epage>568</epage><pages>562-568</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><abstract>Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemokines or chemokine receptors has been shown to delay leukocyte infiltration and prolong graft function, demonstrating an important role for chemokines in allograft rejection.
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| ispartof | Current Opinion in Immunology, 2002-10, Vol.14 (5), p.562-568 |
| issn | 0952-7915 1879-0372 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | allograft infiltration Animals chemokine receptors chemokines Chemokines - physiology Graft Rejection - immunology Humans inflammation ischemia/reperfusion Leukocytes - physiology Receptors, Chemokine - physiology Transplantation Transplantation, Homologous - immunology |
| title | Chemokines: directing leukocyte infiltration into allografts |
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