Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage
Ovarian cancer is the leading cause of death among patients with gynecological cancers, but the biology of these tumors is still among the least understood of all major human malignancies. In this study, comparative genomic hybridization was used to determine chromosomal alterations in 98 stage III...
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Veröffentlicht in: | Genes chromosomes & cancer 2004-08, Vol.40 (4), p.342-348 |
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description | Ovarian cancer is the leading cause of death among patients with gynecological cancers, but the biology of these tumors is still among the least understood of all major human malignancies. In this study, comparative genomic hybridization was used to determine chromosomal alterations in 98 stage III serous papillary adenocarcinomas. The tumors were grouped according to survival and the main prognostic factors stage and surgical outcome. There were chromosomal imbalances that were significantly more common in tumors from patients who died than in tumors from patients who survived: gains of 1q24–qter and losses of 4p, 4q31.1–qter, 5q12–q22, 8p, 16q, and X. Furthermore, we observed that gains of 8q23–8q24.2 and losses of 4p, 4q13–4q26, 4q31.1–qter, 5q12–q22, 8p, and 16q were significantly more common in tumors from patients with macroscopic residual tumor after primary surgery, compared to tumors from those who had undergone radical surgery. Gains of 3q13.3–qter, 6p, 7q21–q31, and 11q13–q23 and losses of 4q31.1–qter and 16q were more common in stage IIIc tumors than in stage IIIa+b tumors. On the basis of our results, we suggest that there are biological differences among the groups mentioned above and that absence of chromosomal aberrations in specific regions predicts a good clinical outcome for individual patients. © 2004 Wiley‐Liss, Inc. |
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In this study, comparative genomic hybridization was used to determine chromosomal alterations in 98 stage III serous papillary adenocarcinomas. The tumors were grouped according to survival and the main prognostic factors stage and surgical outcome. There were chromosomal imbalances that were significantly more common in tumors from patients who died than in tumors from patients who survived: gains of 1q24–qter and losses of 4p, 4q31.1–qter, 5q12–q22, 8p, 16q, and X. Furthermore, we observed that gains of 8q23–8q24.2 and losses of 4p, 4q13–4q26, 4q31.1–qter, 5q12–q22, 8p, and 16q were significantly more common in tumors from patients with macroscopic residual tumor after primary surgery, compared to tumors from those who had undergone radical surgery. Gains of 3q13.3–qter, 6p, 7q21–q31, and 11q13–q23 and losses of 4q31.1–qter and 16q were more common in stage IIIc tumors than in stage IIIa+b tumors. 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Cancer</addtitle><description>Ovarian cancer is the leading cause of death among patients with gynecological cancers, but the biology of these tumors is still among the least understood of all major human malignancies. In this study, comparative genomic hybridization was used to determine chromosomal alterations in 98 stage III serous papillary adenocarcinomas. The tumors were grouped according to survival and the main prognostic factors stage and surgical outcome. There were chromosomal imbalances that were significantly more common in tumors from patients who died than in tumors from patients who survived: gains of 1q24–qter and losses of 4p, 4q31.1–qter, 5q12–q22, 8p, 16q, and X. Furthermore, we observed that gains of 8q23–8q24.2 and losses of 4p, 4q13–4q26, 4q31.1–qter, 5q12–q22, 8p, and 16q were significantly more common in tumors from patients with macroscopic residual tumor after primary surgery, compared to tumors from those who had undergone radical surgery. Gains of 3q13.3–qter, 6p, 7q21–q31, and 11q13–q23 and losses of 4q31.1–qter and 16q were more common in stage IIIc tumors than in stage IIIa+b tumors. On the basis of our results, we suggest that there are biological differences among the groups mentioned above and that absence of chromosomal aberrations in specific regions predicts a good clinical outcome for individual patients. © 2004 Wiley‐Liss, Inc.</description><subject>Chromosome Aberrations - classification</subject><subject>Chromosome Deletion</subject><subject>Cystadenocarcinoma, Papillary - genetics</subject><subject>Cystadenocarcinoma, Papillary - pathology</subject><subject>Cystadenocarcinoma, Papillary - surgery</subject><subject>Cystadenocarcinoma, Serous - genetics</subject><subject>Cystadenocarcinoma, Serous - pathology</subject><subject>Cystadenocarcinoma, Serous - surgery</subject><subject>Cytogenetic Analysis - methods</subject><subject>Female</subject><subject>Gene Amplification - genetics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Survival Rate - trends</subject><subject>Treatment Outcome</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEoqWw4AWQV0hITetLHCfLagTDqFURogiJjXXiHAdDEk_tZGCehlfFcwFWiJV_2d_5jqU_y54zesEo5ZedMRecUikeZKeM1lXOeVk83OVCpizVSfYkxq-U0lLU8nF2wiSrqkJWp9nPqxH6bXSReEvMdvIdjjg5Q6CfMMDk_BiJG0mcoEOyWq1IxODnhG8gOBgJtDh6A8G40Q9AAm4Q-kiAfMEk2Ot2eJeG1um1g9C6sSNxDhu3gf58lzpnoCd-nowf8JzA2KbbZr_yafbIJh8-O55n2cc3r-8Wb_Obd8vV4uomN5JTkZeG2RYqLnltC4GmtciE4C0rVA20EaxAqFXBlVJVa00BVUOlRVqLhlsquDjLXh686-DvZ4yTHlw02Pew_79WnDLOSvlfkKla1ZyrBL46gCb4GANavQ5ugLDVjOpdbTrVpve1JfbFUTo3A7Z_yWNPCbg8AN9dj9t_m_RysfitzA8TLk74488EhG-6VEJJ_el2qa-rz8vrD7fv9Z34BRzYtDc</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Partheen, Karolina</creator><creator>Levan, Kristina</creator><creator>Österberg, Lovisa</creator><creator>Helou, Khalil</creator><creator>Horvath, György</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage</title><author>Partheen, Karolina ; Levan, Kristina ; Österberg, Lovisa ; Helou, Khalil ; Horvath, György</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5203-6c1fda82529f43ecdfe1332d1479a0b314ea97427778dfc4a8b05fe093b2f0323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Chromosome Aberrations - classification</topic><topic>Chromosome Deletion</topic><topic>Cystadenocarcinoma, Papillary - genetics</topic><topic>Cystadenocarcinoma, Papillary - pathology</topic><topic>Cystadenocarcinoma, Papillary - surgery</topic><topic>Cystadenocarcinoma, Serous - genetics</topic><topic>Cystadenocarcinoma, Serous - pathology</topic><topic>Cystadenocarcinoma, Serous - surgery</topic><topic>Cytogenetic Analysis - methods</topic><topic>Female</topic><topic>Gene Amplification - genetics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Survival Rate - trends</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Partheen, Karolina</creatorcontrib><creatorcontrib>Levan, Kristina</creatorcontrib><creatorcontrib>Österberg, Lovisa</creatorcontrib><creatorcontrib>Helou, Khalil</creatorcontrib><creatorcontrib>Horvath, György</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Partheen, Karolina</au><au>Levan, Kristina</au><au>Österberg, Lovisa</au><au>Helou, Khalil</au><au>Horvath, György</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. 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Furthermore, we observed that gains of 8q23–8q24.2 and losses of 4p, 4q13–4q26, 4q31.1–qter, 5q12–q22, 8p, and 16q were significantly more common in tumors from patients with macroscopic residual tumor after primary surgery, compared to tumors from those who had undergone radical surgery. Gains of 3q13.3–qter, 6p, 7q21–q31, and 11q13–q23 and losses of 4q31.1–qter and 16q were more common in stage IIIc tumors than in stage IIIa+b tumors. On the basis of our results, we suggest that there are biological differences among the groups mentioned above and that absence of chromosomal aberrations in specific regions predicts a good clinical outcome for individual patients. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15188458</pmid><doi>10.1002/gcc.20053</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Chromosome Aberrations - classification Chromosome Deletion Cystadenocarcinoma, Papillary - genetics Cystadenocarcinoma, Papillary - pathology Cystadenocarcinoma, Papillary - surgery Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Cystadenocarcinoma, Serous - surgery Cytogenetic Analysis - methods Female Gene Amplification - genetics Humans Karyotyping Neoplasm Staging Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Prognosis Survival Rate - trends Treatment Outcome |
title | Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage |
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