Effect of diazepam on EEG power and coherent activity: sex differences
Benzodiazepine–steroid interactions and sex differences in brain and circulating levels of gonadal steroids, lead to hypothesized differential effects of DZ on EEG in women and men. Coherent activity has been shown to be relevant for binding information into global percepts therefore diazepam effect...
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| Veröffentlicht in: | Psychoneuroendocrinology 2002-10, Vol.27 (7), p.821-833 |
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| creator | Romano-Torres, M Borja-Lascurain, E Chao-Rebolledo, C del-Rı́o-Portilla, Y Corsi-Cabrera, M |
| description | Benzodiazepine–steroid interactions and sex differences in brain and circulating levels of gonadal steroids, lead to hypothesized differential effects of DZ on EEG in women and men. Coherent activity has been shown to be relevant for binding information into global percepts therefore diazepam effects on EEG correlation and sex differences were assessed in a double-blind crossover study.
Healthy males (9) and females (9) received a single-dose (5 mg) of diazepam or placebo. EEG was recorded with eyes open (FP1, FP2, F3, F4, C3, C4, P3, P4, O1, O2) before and 2 h after drug administration in two counterbalanced sessions.
DZ selectively increased
δ and
θ EEG correlation among frontal regions and decreased it between right parieto-occipital (
θ) and fronto-central regions (
α2) in addition to an increase in
β2 interhemispheric correlation in men and women.
Men showed increased
β1 interhemispheric correlation, decreased
α1 and increased
β power; women showed in addition, decreased
θ and
α2 power.
θ rhythm was more sensitive to DZ in women, whereas interhemispheric correlation was more affected in men.
DZ had a sexually dimorphic effect on waking EEG and a disrupting effect on coherent activity, increasing balance among frontal regions and decreasing temporal coupling between anterior–posterior regions. These sex differences might be related to differences in brain organization and activational effects of female gonadal steroids which are higher in women than in men. |
| doi_str_mv | 10.1016/S0306-4530(01)00082-8 |
| format | Article |
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Healthy males (9) and females (9) received a single-dose (5 mg) of diazepam or placebo. EEG was recorded with eyes open (FP1, FP2, F3, F4, C3, C4, P3, P4, O1, O2) before and 2 h after drug administration in two counterbalanced sessions.
DZ selectively increased
δ and
θ EEG correlation among frontal regions and decreased it between right parieto-occipital (
θ) and fronto-central regions (
α2) in addition to an increase in
β2 interhemispheric correlation in men and women.
Men showed increased
β1 interhemispheric correlation, decreased
α1 and increased
β power; women showed in addition, decreased
θ and
α2 power.
θ rhythm was more sensitive to DZ in women, whereas interhemispheric correlation was more affected in men.
DZ had a sexually dimorphic effect on waking EEG and a disrupting effect on coherent activity, increasing balance among frontal regions and decreasing temporal coupling between anterior–posterior regions. These sex differences might be related to differences in brain organization and activational effects of female gonadal steroids which are higher in women than in men.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/S0306-4530(01)00082-8</identifier><identifier>PMID: 12183217</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Analysis of Variance ; Anti-Anxiety Agents - pharmacology ; Behavioral psychophysiology ; Benzodiazepines ; Biological and medical sciences ; Coherent activity ; Diazepam - pharmacology ; Double-Blind Method ; EEG correlation ; Electroencephalography - drug effects ; Electrophysiology ; Female ; Functional Laterality - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Sex Characteristics ; Sex differences ; Spectral power ; Vision, Ocular - physiology ; Women</subject><ispartof>Psychoneuroendocrinology, 2002-10, Vol.27 (7), p.821-833</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-c0a1165cd7b7b7a6a732795de6b3079e2f3c8207b44d44869126d5b2955661ee3</citedby><cites>FETCH-LOGICAL-c443t-c0a1165cd7b7b7a6a732795de6b3079e2f3c8207b44d44869126d5b2955661ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306453001000828$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13899306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12183217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romano-Torres, M</creatorcontrib><creatorcontrib>Borja-Lascurain, E</creatorcontrib><creatorcontrib>Chao-Rebolledo, C</creatorcontrib><creatorcontrib>del-Rı́o-Portilla, Y</creatorcontrib><creatorcontrib>Corsi-Cabrera, M</creatorcontrib><title>Effect of diazepam on EEG power and coherent activity: sex differences</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Benzodiazepine–steroid interactions and sex differences in brain and circulating levels of gonadal steroids, lead to hypothesized differential effects of DZ on EEG in women and men. Coherent activity has been shown to be relevant for binding information into global percepts therefore diazepam effects on EEG correlation and sex differences were assessed in a double-blind crossover study.
Healthy males (9) and females (9) received a single-dose (5 mg) of diazepam or placebo. EEG was recorded with eyes open (FP1, FP2, F3, F4, C3, C4, P3, P4, O1, O2) before and 2 h after drug administration in two counterbalanced sessions.
DZ selectively increased
δ and
θ EEG correlation among frontal regions and decreased it between right parieto-occipital (
θ) and fronto-central regions (
α2) in addition to an increase in
β2 interhemispheric correlation in men and women.
Men showed increased
β1 interhemispheric correlation, decreased
α1 and increased
β power; women showed in addition, decreased
θ and
α2 power.
θ rhythm was more sensitive to DZ in women, whereas interhemispheric correlation was more affected in men.
DZ had a sexually dimorphic effect on waking EEG and a disrupting effect on coherent activity, increasing balance among frontal regions and decreasing temporal coupling between anterior–posterior regions. These sex differences might be related to differences in brain organization and activational effects of female gonadal steroids which are higher in women than in men.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Behavioral psychophysiology</subject><subject>Benzodiazepines</subject><subject>Biological and medical sciences</subject><subject>Coherent activity</subject><subject>Diazepam - pharmacology</subject><subject>Double-Blind Method</subject><subject>EEG correlation</subject><subject>Electroencephalography - drug effects</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Spectral power</subject><subject>Vision, Ocular - physiology</subject><subject>Women</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_gpKLoofVfOxms15EylaFggf1HLLJLEba3Zpsq_XXm35gjzKHgeF5Z4YHoVNKrimh4uaFcCKSNOPkktArQohkidxDfSpznnAuyD7q_yE9dBTCR4SEFOwQ9SijkjOa99GorGswHW5rbJ3-gZme4rbBZfmAZ-0XeKwbi037Dh6aDmvTuYXrlrc4wHcMxGycGwjH6KDWkwAn2z5Ab6PydfiYjJ8fnob348SkKe8SQzSlIjM2r2JpoXPO8iKzICpO8gJYzY1kJK_S1KapFAVlwmYVK7JMCArAB-his3fm2885hE5NXTAwmegG2nlQOSOUFpJFMNuAxrcheKjVzLup9ktFiVoJVGuBamVHEarWApWMubPtgXk1BbtLbY1F4HwL6GD0pPa6MS7sOC6LIi6O3N2Gg6hj4cCrYNzKlXU-Cle2df-88gtsmIqW</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Romano-Torres, M</creator><creator>Borja-Lascurain, E</creator><creator>Chao-Rebolledo, C</creator><creator>del-Rı́o-Portilla, Y</creator><creator>Corsi-Cabrera, M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Effect of diazepam on EEG power and coherent activity: sex differences</title><author>Romano-Torres, M ; Borja-Lascurain, E ; Chao-Rebolledo, C ; del-Rı́o-Portilla, Y ; Corsi-Cabrera, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-c0a1165cd7b7b7a6a732795de6b3079e2f3c8207b44d44869126d5b2955661ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Behavioral psychophysiology</topic><topic>Benzodiazepines</topic><topic>Biological and medical sciences</topic><topic>Coherent activity</topic><topic>Diazepam - pharmacology</topic><topic>Double-Blind Method</topic><topic>EEG correlation</topic><topic>Electroencephalography - drug effects</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Spectral power</topic><topic>Vision, Ocular - physiology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romano-Torres, M</creatorcontrib><creatorcontrib>Borja-Lascurain, E</creatorcontrib><creatorcontrib>Chao-Rebolledo, C</creatorcontrib><creatorcontrib>del-Rı́o-Portilla, Y</creatorcontrib><creatorcontrib>Corsi-Cabrera, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romano-Torres, M</au><au>Borja-Lascurain, E</au><au>Chao-Rebolledo, C</au><au>del-Rı́o-Portilla, Y</au><au>Corsi-Cabrera, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of diazepam on EEG power and coherent activity: sex differences</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>27</volume><issue>7</issue><spage>821</spage><epage>833</epage><pages>821-833</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>Benzodiazepine–steroid interactions and sex differences in brain and circulating levels of gonadal steroids, lead to hypothesized differential effects of DZ on EEG in women and men. Coherent activity has been shown to be relevant for binding information into global percepts therefore diazepam effects on EEG correlation and sex differences were assessed in a double-blind crossover study.
Healthy males (9) and females (9) received a single-dose (5 mg) of diazepam or placebo. EEG was recorded with eyes open (FP1, FP2, F3, F4, C3, C4, P3, P4, O1, O2) before and 2 h after drug administration in two counterbalanced sessions.
DZ selectively increased
δ and
θ EEG correlation among frontal regions and decreased it between right parieto-occipital (
θ) and fronto-central regions (
α2) in addition to an increase in
β2 interhemispheric correlation in men and women.
Men showed increased
β1 interhemispheric correlation, decreased
α1 and increased
β power; women showed in addition, decreased
θ and
α2 power.
θ rhythm was more sensitive to DZ in women, whereas interhemispheric correlation was more affected in men.
DZ had a sexually dimorphic effect on waking EEG and a disrupting effect on coherent activity, increasing balance among frontal regions and decreasing temporal coupling between anterior–posterior regions. These sex differences might be related to differences in brain organization and activational effects of female gonadal steroids which are higher in women than in men.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12183217</pmid><doi>10.1016/S0306-4530(01)00082-8</doi><tpages>13</tpages></addata></record> |
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| subjects | Adult Analysis of Variance Anti-Anxiety Agents - pharmacology Behavioral psychophysiology Benzodiazepines Biological and medical sciences Coherent activity Diazepam - pharmacology Double-Blind Method EEG correlation Electroencephalography - drug effects Electrophysiology Female Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Humans Male Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sex Characteristics Sex differences Spectral power Vision, Ocular - physiology Women |
| title | Effect of diazepam on EEG power and coherent activity: sex differences |
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