Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs
Objective: To investigate effects of prolonged increased intra‐abdominal pressure (IAP) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin. Design: Experimental study. Setting: Haukeland University Hospital, Norway. Animals: 21 domestic pigs. Methods:...
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| Veröffentlicht in: | The European journal of surgery 2002-01, Vol.168 (3), p.178-186 |
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| container_title | The European journal of surgery |
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| creator | Gudmundsson, Fjølnir F Gislason, Hjørtur G Myking, Ole L Viste, Asgaut Grong, Ketil Svanes, Knut |
| description | Objective:
To investigate effects of prolonged increased intra‐abdominal pressure (IAP) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin.
Design:
Experimental study.
Setting:
Haukeland University Hospital, Norway.
Animals:
21 domestic pigs.
Methods:
The IAP was maintained at normal (n = 7) or at 20 mmHg (n = 7) or 30 mmHg (n = 7) for three hours.
Main outcome measures:
Urine output, renal venous pressure, renal artery blood flow (transit‐time flowmetry), renal cortex blood flow (microspheres), and renin, aldosterone, atrial natriuretic factor (ANF), adrenaline, noradrenaline, cortisol, and endothelin‐1 (ET‐1) in renal venous blood.
Results:
An IAP of 20 mmHg was followed by no significant changes in the variables studied. An IAP of 30 mmHg was associated with anuria, considerably reduced renal blood flow and increased renal vascular resistance. The renin activity and the blood concentrations of ET‐1, aldosterone, noradrenaline, adrenaline, and cortisol increased during the three hours that IAP was at 30 mmHg.
Conclusion:
An IAP of 20 mmHg did not influence renal haemodynamics or diuresis. The low renal blood flow observed at an IAP of 30 mmHg probably results from reduced arteriovenous pressure difference and vasoconstriction. Increased concentrations of endothelin, angiotensin II, and noradrenaline may account for the vasoconstriction. The anuria can be explained by low renal blood flow and increased reabsorption of sodium in renal tubules caused by aldosterone. Copyright © 2002 Taylor and Francis Ltd. |
| doi_str_mv | 10.1080/110241502320127801 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72010824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72010824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4133-fb6a34940758fa6289ad003790290680479b30cdb439b9a2f9361f5fa47d98133</originalsourceid><addsrcrecordid>eNqNkM1u1TAQhS0EoqXwAiyQN7ALHf8kjpeoKi3oFiQulKU1iZ0ScOLUTlS674PjcK_ogk1Xc6T5zhn7EPKSwVsGNRwzBlyyErjgwLiqgT0ih0xJVmiu2OOsM1Bkgh2QZyn9BAAmFH9KDhhnNedSHpK78xCHMKKn7Q8cr1yi0XmcnaVzyNIubZbRrUDjQ7C08-GG4mjpOpfYj46GZZ6WmS6jdZFOMfiQgyztxzY6TH_VHLHAxoahX5Om6FJaossLOvVX6Tl50qFP7sV-HpFv70-_npwXm89nH07ebYpWMiGKrqlQSC1BlXWHFa81WgChNHANVQ1S6UZAaxspdKORd1pUrCs7lMrqOicckTe73PzI68Wl2Qx9ap33OLqwJKNyj1BzmUG-A9sYUoquM1PsB4y3hoFZuzf_d59Nr_bpSzM4e2_Zl52B13sAU4u-izi2fbrnhFJVVdaZK3fcTe_d7QNOm9OPW7V-r9j5-jS73_98GH-ZSglVmu-fzkx5sb3cqi-XZiP-AIBMqqI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72010824</pqid></control><display><type>article</type><title>Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Gudmundsson, Fjølnir F ; Gislason, Hjørtur G ; Myking, Ole L ; Viste, Asgaut ; Grong, Ketil ; Svanes, Knut</creator><creatorcontrib>Gudmundsson, Fjølnir F ; Gislason, Hjørtur G ; Myking, Ole L ; Viste, Asgaut ; Grong, Ketil ; Svanes, Knut</creatorcontrib><description>Objective:
To investigate effects of prolonged increased intra‐abdominal pressure (IAP) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin.
Design:
Experimental study.
Setting:
Haukeland University Hospital, Norway.
Animals:
21 domestic pigs.
Methods:
The IAP was maintained at normal (n = 7) or at 20 mmHg (n = 7) or 30 mmHg (n = 7) for three hours.
Main outcome measures:
Urine output, renal venous pressure, renal artery blood flow (transit‐time flowmetry), renal cortex blood flow (microspheres), and renin, aldosterone, atrial natriuretic factor (ANF), adrenaline, noradrenaline, cortisol, and endothelin‐1 (ET‐1) in renal venous blood.
Results:
An IAP of 20 mmHg was followed by no significant changes in the variables studied. An IAP of 30 mmHg was associated with anuria, considerably reduced renal blood flow and increased renal vascular resistance. The renin activity and the blood concentrations of ET‐1, aldosterone, noradrenaline, adrenaline, and cortisol increased during the three hours that IAP was at 30 mmHg.
Conclusion:
An IAP of 20 mmHg did not influence renal haemodynamics or diuresis. The low renal blood flow observed at an IAP of 30 mmHg probably results from reduced arteriovenous pressure difference and vasoconstriction. Increased concentrations of endothelin, angiotensin II, and noradrenaline may account for the vasoconstriction. The anuria can be explained by low renal blood flow and increased reabsorption of sodium in renal tubules caused by aldosterone. Copyright © 2002 Taylor and Francis Ltd.</description><identifier>ISSN: 1102-4151</identifier><identifier>EISSN: 1741-9271</identifier><identifier>DOI: 10.1080/110241502320127801</identifier><identifier>PMID: 12182244</identifier><language>eng</language><publisher>UK: Taylor & Francis, Ltd</publisher><subject>abdominal compartment syndrome ; adrenaline ; aldosterone ; Animals ; Biological and medical sciences ; cortisol ; Diuresis ; endothelin ; Endothelins - metabolism ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; hemodynamics ; hormones ; Hormones - metabolism ; kidney ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; noradrenaline ; Other diseases. Semiology ; Pressure ; renal blood flow ; Renal Circulation ; renal physiology ; renin ; Renin-Angiotensin System - physiology ; Swine ; Vascular Resistance</subject><ispartof>The European journal of surgery, 2002-01, Vol.168 (3), p.178-186</ispartof><rights>Copyright © 2002 Taylor and Francis Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4133-fb6a34940758fa6289ad003790290680479b30cdb439b9a2f9361f5fa47d98133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13776658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12182244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gudmundsson, Fjølnir F</creatorcontrib><creatorcontrib>Gislason, Hjørtur G</creatorcontrib><creatorcontrib>Myking, Ole L</creatorcontrib><creatorcontrib>Viste, Asgaut</creatorcontrib><creatorcontrib>Grong, Ketil</creatorcontrib><creatorcontrib>Svanes, Knut</creatorcontrib><title>Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs</title><title>The European journal of surgery</title><addtitle>Eur J Surg</addtitle><description>Objective:
To investigate effects of prolonged increased intra‐abdominal pressure (IAP) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin.
Design:
Experimental study.
Setting:
Haukeland University Hospital, Norway.
Animals:
21 domestic pigs.
Methods:
The IAP was maintained at normal (n = 7) or at 20 mmHg (n = 7) or 30 mmHg (n = 7) for three hours.
Main outcome measures:
Urine output, renal venous pressure, renal artery blood flow (transit‐time flowmetry), renal cortex blood flow (microspheres), and renin, aldosterone, atrial natriuretic factor (ANF), adrenaline, noradrenaline, cortisol, and endothelin‐1 (ET‐1) in renal venous blood.
Results:
An IAP of 20 mmHg was followed by no significant changes in the variables studied. An IAP of 30 mmHg was associated with anuria, considerably reduced renal blood flow and increased renal vascular resistance. The renin activity and the blood concentrations of ET‐1, aldosterone, noradrenaline, adrenaline, and cortisol increased during the three hours that IAP was at 30 mmHg.
Conclusion:
An IAP of 20 mmHg did not influence renal haemodynamics or diuresis. The low renal blood flow observed at an IAP of 30 mmHg probably results from reduced arteriovenous pressure difference and vasoconstriction. Increased concentrations of endothelin, angiotensin II, and noradrenaline may account for the vasoconstriction. The anuria can be explained by low renal blood flow and increased reabsorption of sodium in renal tubules caused by aldosterone. Copyright © 2002 Taylor and Francis Ltd.</description><subject>abdominal compartment syndrome</subject><subject>adrenaline</subject><subject>aldosterone</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cortisol</subject><subject>Diuresis</subject><subject>endothelin</subject><subject>Endothelins - metabolism</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hemodynamics</subject><subject>hormones</subject><subject>Hormones - metabolism</subject><subject>kidney</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>noradrenaline</subject><subject>Other diseases. Semiology</subject><subject>Pressure</subject><subject>renal blood flow</subject><subject>Renal Circulation</subject><subject>renal physiology</subject><subject>renin</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Swine</subject><subject>Vascular Resistance</subject><issn>1102-4151</issn><issn>1741-9271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1TAQhS0EoqXwAiyQN7ALHf8kjpeoKi3oFiQulKU1iZ0ScOLUTlS674PjcK_ogk1Xc6T5zhn7EPKSwVsGNRwzBlyyErjgwLiqgT0ih0xJVmiu2OOsM1Bkgh2QZyn9BAAmFH9KDhhnNedSHpK78xCHMKKn7Q8cr1yi0XmcnaVzyNIubZbRrUDjQ7C08-GG4mjpOpfYj46GZZ6WmS6jdZFOMfiQgyztxzY6TH_VHLHAxoahX5Om6FJaossLOvVX6Tl50qFP7sV-HpFv70-_npwXm89nH07ebYpWMiGKrqlQSC1BlXWHFa81WgChNHANVQ1S6UZAaxspdKORd1pUrCs7lMrqOicckTe73PzI68Wl2Qx9ap33OLqwJKNyj1BzmUG-A9sYUoquM1PsB4y3hoFZuzf_d59Nr_bpSzM4e2_Zl52B13sAU4u-izi2fbrnhFJVVdaZK3fcTe_d7QNOm9OPW7V-r9j5-jS73_98GH-ZSglVmu-fzkx5sb3cqi-XZiP-AIBMqqI</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Gudmundsson, Fjølnir F</creator><creator>Gislason, Hjørtur G</creator><creator>Myking, Ole L</creator><creator>Viste, Asgaut</creator><creator>Grong, Ketil</creator><creator>Svanes, Knut</creator><general>Taylor & Francis, Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs</title><author>Gudmundsson, Fjølnir F ; Gislason, Hjørtur G ; Myking, Ole L ; Viste, Asgaut ; Grong, Ketil ; Svanes, Knut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4133-fb6a34940758fa6289ad003790290680479b30cdb439b9a2f9361f5fa47d98133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>abdominal compartment syndrome</topic><topic>adrenaline</topic><topic>aldosterone</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cortisol</topic><topic>Diuresis</topic><topic>endothelin</topic><topic>Endothelins - metabolism</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hemodynamics</topic><topic>hormones</topic><topic>Hormones - metabolism</topic><topic>kidney</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>noradrenaline</topic><topic>Other diseases. Semiology</topic><topic>Pressure</topic><topic>renal blood flow</topic><topic>Renal Circulation</topic><topic>renal physiology</topic><topic>renin</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Swine</topic><topic>Vascular Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gudmundsson, Fjølnir F</creatorcontrib><creatorcontrib>Gislason, Hjørtur G</creatorcontrib><creatorcontrib>Myking, Ole L</creatorcontrib><creatorcontrib>Viste, Asgaut</creatorcontrib><creatorcontrib>Grong, Ketil</creatorcontrib><creatorcontrib>Svanes, Knut</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gudmundsson, Fjølnir F</au><au>Gislason, Hjørtur G</au><au>Myking, Ole L</au><au>Viste, Asgaut</au><au>Grong, Ketil</au><au>Svanes, Knut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs</atitle><jtitle>The European journal of surgery</jtitle><addtitle>Eur J Surg</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>168</volume><issue>3</issue><spage>178</spage><epage>186</epage><pages>178-186</pages><issn>1102-4151</issn><eissn>1741-9271</eissn><abstract>Objective:
To investigate effects of prolonged increased intra‐abdominal pressure (IAP) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin.
Design:
Experimental study.
Setting:
Haukeland University Hospital, Norway.
Animals:
21 domestic pigs.
Methods:
The IAP was maintained at normal (n = 7) or at 20 mmHg (n = 7) or 30 mmHg (n = 7) for three hours.
Main outcome measures:
Urine output, renal venous pressure, renal artery blood flow (transit‐time flowmetry), renal cortex blood flow (microspheres), and renin, aldosterone, atrial natriuretic factor (ANF), adrenaline, noradrenaline, cortisol, and endothelin‐1 (ET‐1) in renal venous blood.
Results:
An IAP of 20 mmHg was followed by no significant changes in the variables studied. An IAP of 30 mmHg was associated with anuria, considerably reduced renal blood flow and increased renal vascular resistance. The renin activity and the blood concentrations of ET‐1, aldosterone, noradrenaline, adrenaline, and cortisol increased during the three hours that IAP was at 30 mmHg.
Conclusion:
An IAP of 20 mmHg did not influence renal haemodynamics or diuresis. The low renal blood flow observed at an IAP of 30 mmHg probably results from reduced arteriovenous pressure difference and vasoconstriction. Increased concentrations of endothelin, angiotensin II, and noradrenaline may account for the vasoconstriction. The anuria can be explained by low renal blood flow and increased reabsorption of sodium in renal tubules caused by aldosterone. Copyright © 2002 Taylor and Francis Ltd.</abstract><cop>UK</cop><pub>Taylor & Francis, Ltd</pub><pmid>12182244</pmid><doi>10.1080/110241502320127801</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1102-4151 |
| ispartof | The European journal of surgery, 2002-01, Vol.168 (3), p.178-186 |
| issn | 1102-4151 1741-9271 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | abdominal compartment syndrome adrenaline aldosterone Animals Biological and medical sciences cortisol Diuresis endothelin Endothelins - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen hemodynamics hormones Hormones - metabolism kidney Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences noradrenaline Other diseases. Semiology Pressure renal blood flow Renal Circulation renal physiology renin Renin-Angiotensin System - physiology Swine Vascular Resistance |
| title | Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs |
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