Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i)

RGS2 and RGS4 were studied for their effects as GTPase activating proteins (GAPs) on receptor-activated G(i) in a novel steady-state assay using membranes from Sf9 cells quadruply infected with baculoviruses encoding the m2 muscarinic receptor, G(alphai2), G(beta1), and G(gamma2). In the presence of...

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Veröffentlicht in:	Molecular pharmacology 2002-09, Vol.62 (3), p.654-659
Hauptverfasser:	Cladman, Wendy, Chidiac, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Dose-Response Relationship, Drug GTP-Binding Protein alpha Subunits, Gi-Go - metabolism GTP-Binding Proteins GTPase-Activating Proteins - metabolism Insecta Receptor, Muscarinic M2 Receptors, Muscarinic - metabolism RGS Proteins - metabolism Salts - pharmacology
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