Explorations in Organic Chemistry Leading to the Total Synthesis of (±)-Gelsemine

The total synthesis of (±)-gelsemine (1) is described. A defining phase of the effort involved recourse to a strategic oxetane ring (see compound 25). It was constructed anticipating an intramolecular displacement of the carbon (C17)−oxygen (O4) bond (see product 48). A key intermediate in the stere...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2002-08, Vol.124 (33), p.9812-9824
Hauptverfasser:	Ng, Fay W, Lin, Hong, Danishefsky, Samuel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!