Activation of Phosphoinositide 3-Kinases by the CCR4 Ligand Macrophage-Derived Chemokine Is a Dispensable Signal for T Lymphocyte Chemotaxis

Macrophage-derived chemokine (MDC/CC chemokine ligand 22 (CCL22)) mediates its cellular effects principally by binding to its receptor CCR4, and together they constitute a multifunctional chemokine/receptor system with homeostatic and inflammatory roles in the body. We report the CCL22-induced accum...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-06, Vol.172 (12), p.7761-7770
Hauptverfasser:	Cronshaw, Darran G, Owen, Charles, Brown, Zarin, Ward, Stephen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cells, Cultured Chemokine CCL22 Chemokines, CC - metabolism Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology Enzyme Activation Humans Intracellular Signaling Peptides and Proteins Ligands Pertussis Toxin - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Receptors, CCR4 Receptors, Chemokine - metabolism rho-Associated Kinases T-Lymphocytes - physiology Th2 Cells - immunology
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