Calcitonin gene-related peptide partially reverses decreased production of chemokines KC and MIP-2 following murine sepsis

The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation...

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Veröffentlicht in:	Inflammation 2002-08, Vol.26 (4), p.167-174
Hauptverfasser:	Wang, Xian, Ebong, Samuel J, Call, Douglas R, Newcomb, David E, Bolgos, Gerald R, Remick, Daniel G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections - blood Bacterial Infections - metabolism Calcitonin Gene-Related Peptide - pharmacology Chemokine CXCL1 Chemokine CXCL2 Chemokines - biosynthesis Chemokines - metabolism Chemokines, CXC Chemotactic Factors - biosynthesis Chemotactic Factors - metabolism Female Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - metabolism Interleukin-6 - blood Interleukin-6 - metabolism Leukocyte Count Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice Mice, Inbred BALB C Peritoneum - metabolism
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