An Effective Procedure for the Acylation of Azaindoles at C-3

Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl3 in CH2Cl2 followed by the addition of an acyl chloride at room temperature.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2002-08, Vol.67 (17), p.6226-6227
Hauptverfasser:	Zhang, Zhongxing, Yang, Zhong, Wong, Henry, Zhu, Juliang, Meanwell, Nicholas A, Kadow, John F, Wang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl3 in CH2Cl2 followed by the addition of an acyl chloride at room temperature.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo020135i