Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cells

Interactions among p53, bcl‐2 and Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma (NPC) cells were evaluated by gene cotransfections. The data showed that bcl‐2 expression was not only able to prevent the growth suppression induced by wild‐type p53 but was also...

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Veröffentlicht in:	Pathology international 2004-07, Vol.54 (7), p.475-485
Hauptverfasser:	Sheu, Lai-Fa, Chen, An, Lee, Herng-Sheng, Hsu, Hsue-Yin, Yu, Da-Shung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism bcl-2 Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Epstein-Barr virus Gene Expression Regulation, Neoplastic Humans latent membrane protein 1 nasopharyngeal carcinoma Nasopharyngeal Neoplasms - metabolism p53 Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Transfection Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism
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