Chiral investigation of midodrine, a long-acting α-adrenergic stimulating agent

Midodrine hydrochloride is a peripheral α1‐adrenoreceptor agonist that induces venous and arterial vasoconstriction. Midodrine, after oral or intravenous administration, undergoes enzymatic hydrolysis and releases deglymidodrine, a pharmacologically active metabolite. Midodrine and deglymidodrine ha...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2004, Vol.16 (6), p.356-362
Hauptverfasser:	Quaglia, M.G., Farina, A., Palmery, M., Desideri, N., Donati, E., Bossù, E., Strano, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - chemistry Adrenergic alpha-Agonists - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - pathology Carbon - chemistry chiral chromatography deglymidodrine Dose-Response Relationship, Drug Electrophoresis, Capillary Hydrolysis midodrine Midodrine - analogs & derivatives Midodrine - chemistry Midodrine - pharmacology Models, Chemical pure enantiomer Rabbits racemates Stereoisomerism
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