c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations

To investigate the incidence of Fas (exon 9) mutations and the expression of Fas, Fas-Fas ligand (FasL) system, and cellular FLICE-like inhibitory protein (c-FLIP) in relation to standard clinicopathologic parameters and patient outcome in bladder carcinoma. Disruption of apoptotic cell death has be...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2004-06, Vol.63 (6), p.1198-1204
Hauptverfasser:	Korkolopoulou, Penelope, Goudopoulou, Athina, Voutsinas, Gerassimos, Thomas-Tsagli, Euphemia, Kapralos, Panagiotis, Patsouris, Efstratios, Saetta, Angelica A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis Biological and medical sciences Carcinoma - metabolism Carcinoma - pathology Carrier Proteins - metabolism CASP8 and FADD-Like Apoptosis Regulating Protein Fas Ligand Protein fas Receptor Female Follow-Up Studies Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins Male Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Middle Aged Multivariate Analysis Mutation Neoplasm Invasiveness - physiopathology Neoplasm Staging Nephrology. Urinary tract diseases Proteins - metabolism Receptors, Tumor Necrosis Factor Survival Analysis Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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