Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions

The present studies evaluated the ability of injectable, biodegradable microspheres releasing carboplatin, doxorubicin, or 5-fluorouracil to suppress the growth of solid tumors implanted subcutaneously or intramuscularly. Seven to 10 days after implantation of MATB-III cells, rats received systemic...

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Veröffentlicht in:	Pharmaceutical research 2002-07, Vol.19 (7), p.1052-1060
Hauptverfasser:	EMERICH, Dwaine F, SNODGRASS, Pamela, LAFRENIERE, Denise, DEAN, Reginald L, SALZBERG, Heather, MARSH, Joanne, PERDOMO, Brigido, ARASTU, Mahin, WINN, Shelley R, BARTUS, Raymond T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Biological and medical sciences Chemotherapy Delayed-Action Preparations - administration & dosage Dose-Response Relationship, Drug General pharmacology Infusions, Parenteral Injections, Intralesional Injections, Intramuscular Injections, Subcutaneous Male Medical sciences Microspheres Neoplasm Transplantation - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Inbred F344 Tumor Cells, Cultured - transplantation Xenograft Model Antitumor Assays - methods
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