Diet and Melanoma in a Case-Control Study
Background: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. Methods: Newly diagnosed patients with melanoma ( n = 502) were rec...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-06, Vol.13 (6), p.1042-1051 |
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| creator | MILLEN, Amy E TUCKER, Margaret A HARTGE, Patricia HALPERN, Allan ELDER, David E GUERRY, Dupont HOLLY, Elizabeth A SAGEBIEL, Richard W POTISCHMAN, Nancy |
| description | Background: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable
risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. Methods: Newly diagnosed
patients with melanoma ( n = 502) were recruited from pigment lesion clinics and controls ( n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this
case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the
previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. Results:
Persons in high versus low quintiles of energy-adjusted vitamin D, α-carotene, β-carotene, cryptoxanthin, lutein, and lycopene
had significantly reduced risk for melanoma (ORs ≤ 0.67), which remained after adjustment for presence of dysplastic nevi,
education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional
reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment
for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. Conclusions: Diets consisting
of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These
analyses should be repeated in large, prospective studies. |
| doi_str_mv | 10.1158/1055-9965.1042.13.6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72005288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72005288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-2e075bde2251786daf92e9efef6f6b9382e61c7ba13b5c2c9b72702ea748a06e3</originalsourceid><addsrcrecordid>eNpN0MlOwzAQBmALgWgpPAESygUEhwQv8ZIjCqtUxAE4W44zoUFZip0I9e1J2iA4eQ7fzHh-hE4Jjgjh6ppgzsMkETwiOKYRYZHYQ3PCmQql5Hx_qH_FDB15_4kxlgnnh2hGOFExFXSOrm5L6ALT5MEzVKZpaxOUTWCC1HgI07bpXFsFr12fb47RQWEqDyfTu0Dv93dv6WO4fHl4Sm-WoY1x0oUUsORZDpRyIpXITZFQSKCAQhQiS5iiIIiVmSEs45baJJNUYgpGxspgAWyBLnZz16796sF3ui69hWr4HbS915JizKlSA2Q7aF3rvYNCr11ZG7fRBOsxIT3er8f79ZiQJkyLoetsGt9nNeR_PVMkAzifgPHWVIUzjS39P6eYEDge3OXOrcqP1XfpQNtBgnPgwTi72q7bLmY_Ms150w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72005288</pqid></control><display><type>article</type><title>Diet and Melanoma in a Case-Control Study</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MILLEN, Amy E ; TUCKER, Margaret A ; HARTGE, Patricia ; HALPERN, Allan ; ELDER, David E ; GUERRY, Dupont ; HOLLY, Elizabeth A ; SAGEBIEL, Richard W ; POTISCHMAN, Nancy</creator><creatorcontrib>MILLEN, Amy E ; TUCKER, Margaret A ; HARTGE, Patricia ; HALPERN, Allan ; ELDER, David E ; GUERRY, Dupont ; HOLLY, Elizabeth A ; SAGEBIEL, Richard W ; POTISCHMAN, Nancy</creatorcontrib><description>Background: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable
risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. Methods: Newly diagnosed
patients with melanoma ( n = 502) were recruited from pigment lesion clinics and controls ( n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this
case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the
previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. Results:
Persons in high versus low quintiles of energy-adjusted vitamin D, α-carotene, β-carotene, cryptoxanthin, lutein, and lycopene
had significantly reduced risk for melanoma (ORs ≤ 0.67), which remained after adjustment for presence of dysplastic nevi,
education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional
reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment
for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. Conclusions: Diets consisting
of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These
analyses should be repeated in large, prospective studies.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.1042.13.6</identifier><identifier>PMID: 15184262</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject><![CDATA[Adult ; Aged ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Carotenoids - administration & dosage ; Case-Control Studies ; Dermatology ; Diet - statistics & numerical data ; Diet Surveys ; Female ; Humans ; Linoleic Acid - administration & dosage ; Logistic Models ; Male ; Medical sciences ; Melanoma - epidemiology ; Melanoma - prevention & control ; Micronutrients - analysis ; Middle Aged ; Philadelphia - epidemiology ; Risk Factors ; San Francisco - epidemiology ; Skin Neoplasms - epidemiology ; Skin Neoplasms - prevention & control ; Sunlight - adverse effects ; Tumors of the skin and soft tissue. Premalignant lesions ; Vitamins - administration & dosage]]></subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2004-06, Vol.13 (6), p.1042-1051</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-2e075bde2251786daf92e9efef6f6b9382e61c7ba13b5c2c9b72702ea748a06e3</citedby><cites>FETCH-LOGICAL-c409t-2e075bde2251786daf92e9efef6f6b9382e61c7ba13b5c2c9b72702ea748a06e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15836604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15184262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MILLEN, Amy E</creatorcontrib><creatorcontrib>TUCKER, Margaret A</creatorcontrib><creatorcontrib>HARTGE, Patricia</creatorcontrib><creatorcontrib>HALPERN, Allan</creatorcontrib><creatorcontrib>ELDER, David E</creatorcontrib><creatorcontrib>GUERRY, Dupont</creatorcontrib><creatorcontrib>HOLLY, Elizabeth A</creatorcontrib><creatorcontrib>SAGEBIEL, Richard W</creatorcontrib><creatorcontrib>POTISCHMAN, Nancy</creatorcontrib><title>Diet and Melanoma in a Case-Control Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable
risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. Methods: Newly diagnosed
patients with melanoma ( n = 502) were recruited from pigment lesion clinics and controls ( n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this
case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the
previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. Results:
Persons in high versus low quintiles of energy-adjusted vitamin D, α-carotene, β-carotene, cryptoxanthin, lutein, and lycopene
had significantly reduced risk for melanoma (ORs ≤ 0.67), which remained after adjustment for presence of dysplastic nevi,
education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional
reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment
for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. Conclusions: Diets consisting
of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These
analyses should be repeated in large, prospective studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - administration & dosage</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>Diet - statistics & numerical data</subject><subject>Diet Surveys</subject><subject>Female</subject><subject>Humans</subject><subject>Linoleic Acid - administration & dosage</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - epidemiology</subject><subject>Melanoma - prevention & control</subject><subject>Micronutrients - analysis</subject><subject>Middle Aged</subject><subject>Philadelphia - epidemiology</subject><subject>Risk Factors</subject><subject>San Francisco - epidemiology</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Sunlight - adverse effects</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Vitamins - administration & dosage</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0MlOwzAQBmALgWgpPAESygUEhwQv8ZIjCqtUxAE4W44zoUFZip0I9e1J2iA4eQ7fzHh-hE4Jjgjh6ppgzsMkETwiOKYRYZHYQ3PCmQql5Hx_qH_FDB15_4kxlgnnh2hGOFExFXSOrm5L6ALT5MEzVKZpaxOUTWCC1HgI07bpXFsFr12fb47RQWEqDyfTu0Dv93dv6WO4fHl4Sm-WoY1x0oUUsORZDpRyIpXITZFQSKCAQhQiS5iiIIiVmSEs45baJJNUYgpGxspgAWyBLnZz16796sF3ui69hWr4HbS915JizKlSA2Q7aF3rvYNCr11ZG7fRBOsxIT3er8f79ZiQJkyLoetsGt9nNeR_PVMkAzifgPHWVIUzjS39P6eYEDge3OXOrcqP1XfpQNtBgnPgwTi72q7bLmY_Ms150w</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>MILLEN, Amy E</creator><creator>TUCKER, Margaret A</creator><creator>HARTGE, Patricia</creator><creator>HALPERN, Allan</creator><creator>ELDER, David E</creator><creator>GUERRY, Dupont</creator><creator>HOLLY, Elizabeth A</creator><creator>SAGEBIEL, Richard W</creator><creator>POTISCHMAN, Nancy</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Diet and Melanoma in a Case-Control Study</title><author>MILLEN, Amy E ; TUCKER, Margaret A ; HARTGE, Patricia ; HALPERN, Allan ; ELDER, David E ; GUERRY, Dupont ; HOLLY, Elizabeth A ; SAGEBIEL, Richard W ; POTISCHMAN, Nancy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-2e075bde2251786daf92e9efef6f6b9382e61c7ba13b5c2c9b72702ea748a06e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - administration & dosage</topic><topic>Case-Control Studies</topic><topic>Dermatology</topic><topic>Diet - statistics & numerical data</topic><topic>Diet Surveys</topic><topic>Female</topic><topic>Humans</topic><topic>Linoleic Acid - administration & dosage</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - epidemiology</topic><topic>Melanoma - prevention & control</topic><topic>Micronutrients - analysis</topic><topic>Middle Aged</topic><topic>Philadelphia - epidemiology</topic><topic>Risk Factors</topic><topic>San Francisco - epidemiology</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Sunlight - adverse effects</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Vitamins - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILLEN, Amy E</creatorcontrib><creatorcontrib>TUCKER, Margaret A</creatorcontrib><creatorcontrib>HARTGE, Patricia</creatorcontrib><creatorcontrib>HALPERN, Allan</creatorcontrib><creatorcontrib>ELDER, David E</creatorcontrib><creatorcontrib>GUERRY, Dupont</creatorcontrib><creatorcontrib>HOLLY, Elizabeth A</creatorcontrib><creatorcontrib>SAGEBIEL, Richard W</creatorcontrib><creatorcontrib>POTISCHMAN, Nancy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILLEN, Amy E</au><au>TUCKER, Margaret A</au><au>HARTGE, Patricia</au><au>HALPERN, Allan</au><au>ELDER, David E</au><au>GUERRY, Dupont</au><au>HOLLY, Elizabeth A</au><au>SAGEBIEL, Richard W</au><au>POTISCHMAN, Nancy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet and Melanoma in a Case-Control Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>13</volume><issue>6</issue><spage>1042</spage><epage>1051</epage><pages>1042-1051</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Background: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable
risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. Methods: Newly diagnosed
patients with melanoma ( n = 502) were recruited from pigment lesion clinics and controls ( n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this
case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the
previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. Results:
Persons in high versus low quintiles of energy-adjusted vitamin D, α-carotene, β-carotene, cryptoxanthin, lutein, and lycopene
had significantly reduced risk for melanoma (ORs ≤ 0.67), which remained after adjustment for presence of dysplastic nevi,
education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional
reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment
for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. Conclusions: Diets consisting
of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These
analyses should be repeated in large, prospective studies.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15184262</pmid><doi>10.1158/1055-9965.1042.13.6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2004-06, Vol.13 (6), p.1042-1051 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Alcohol Drinking - adverse effects Biological and medical sciences Carotenoids - administration & dosage Case-Control Studies Dermatology Diet - statistics & numerical data Diet Surveys Female Humans Linoleic Acid - administration & dosage Logistic Models Male Medical sciences Melanoma - epidemiology Melanoma - prevention & control Micronutrients - analysis Middle Aged Philadelphia - epidemiology Risk Factors San Francisco - epidemiology Skin Neoplasms - epidemiology Skin Neoplasms - prevention & control Sunlight - adverse effects Tumors of the skin and soft tissue. Premalignant lesions Vitamins - administration & dosage |
| title | Diet and Melanoma in a Case-Control Study |
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