Human T cell lymphotropic virus (HTLV) type-1-specific CD8+T cells: Frequency and immunodominance hierarchy
Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma enzyme-linked immunospot assays with overlapping peptides spanning the entire HTLV-1 proteome to test whether the HTLV-1-specific CD8(+) T cells diffe...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-06, Vol.189 (12), p.2294-2298 |
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| container_title | The Journal of infectious diseases |
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| creator | GOON, Peter K. C BIANCARDI, Alix BANGHAM, Charles R. M FAST, Noam IGAKURA, Tadahiko HANON, Emmanuel MOSLEY, Angelina J ASQUITH, Becca GOULD, Keith G MARSHALL, Sara TAYLOR, Graham P |
| description | Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma enzyme-linked immunospot assays with overlapping peptides spanning the entire HTLV-1 proteome to test whether the HTLV-1-specific CD8(+) T cells differed significantly in frequency or immunodominance hierarchy between patients with HAM/TSP and asymptomatic carriers and whether the frequency correlated with provirus load. Tax was the immunodominant target antigen. There was no significant qualitative or quantitative difference in the HTLV-1-specific CD8(+) T cell response between the 2 groups. Virus-specific CD8(+) T cell frequency alone does not indicate the effectiveness of the cytotoxic T lymphocyte response in controlling provirus load at equilibrium. |
| doi_str_mv | 10.1086/420832 |
| format | Article |
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C ; BIANCARDI, Alix ; BANGHAM, Charles R. M ; FAST, Noam ; IGAKURA, Tadahiko ; HANON, Emmanuel ; MOSLEY, Angelina J ; ASQUITH, Becca ; GOULD, Keith G ; MARSHALL, Sara ; TAYLOR, Graham P</creator><creatorcontrib>GOON, Peter K. C ; BIANCARDI, Alix ; BANGHAM, Charles R. M ; FAST, Noam ; IGAKURA, Tadahiko ; HANON, Emmanuel ; MOSLEY, Angelina J ; ASQUITH, Becca ; GOULD, Keith G ; MARSHALL, Sara ; TAYLOR, Graham P</creatorcontrib><description>Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma enzyme-linked immunospot assays with overlapping peptides spanning the entire HTLV-1 proteome to test whether the HTLV-1-specific CD8(+) T cells differed significantly in frequency or immunodominance hierarchy between patients with HAM/TSP and asymptomatic carriers and whether the frequency correlated with provirus load. Tax was the immunodominant target antigen. There was no significant qualitative or quantitative difference in the HTLV-1-specific CD8(+) T cell response between the 2 groups. Virus-specific CD8(+) T cell frequency alone does not indicate the effectiveness of the cytotoxic T lymphocyte response in controlling provirus load at equilibrium.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/420832</identifier><identifier>PMID: 15181578</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Biological and medical sciences ; Carrier State - immunology ; CD8-Positive T-Lymphocytes - immunology ; Epitopes, T-Lymphocyte - immunology ; Fundamental and applied biological sciences. Psychology ; HTLV-I Infections - immunology ; HTLV-I Infections - virology ; Human T-lymphotropic virus 1 - immunology ; Humans ; Immunodominant Epitopes - immunology ; Infectious diseases ; Interferon-gamma - biosynthesis ; Medical sciences ; Microbiology ; Miscellaneous ; Paraparesis, Tropical Spastic - immunology ; Peptides - immunology ; Virology</subject><ispartof>The Journal of infectious diseases, 2004-06, Vol.189 (12), p.2294-2298</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 15 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-cab4412c1879eb0bf30abb3ae9ced6c67227a03651eb28016d30ee41e45ecfdc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15959798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15181578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOON, Peter K. C</creatorcontrib><creatorcontrib>BIANCARDI, Alix</creatorcontrib><creatorcontrib>BANGHAM, Charles R. M</creatorcontrib><creatorcontrib>FAST, Noam</creatorcontrib><creatorcontrib>IGAKURA, Tadahiko</creatorcontrib><creatorcontrib>HANON, Emmanuel</creatorcontrib><creatorcontrib>MOSLEY, Angelina J</creatorcontrib><creatorcontrib>ASQUITH, Becca</creatorcontrib><creatorcontrib>GOULD, Keith G</creatorcontrib><creatorcontrib>MARSHALL, Sara</creatorcontrib><creatorcontrib>TAYLOR, Graham P</creatorcontrib><title>Human T cell lymphotropic virus (HTLV) type-1-specific CD8+T cells: Frequency and immunodominance hierarchy</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma enzyme-linked immunospot assays with overlapping peptides spanning the entire HTLV-1 proteome to test whether the HTLV-1-specific CD8(+) T cells differed significantly in frequency or immunodominance hierarchy between patients with HAM/TSP and asymptomatic carriers and whether the frequency correlated with provirus load. Tax was the immunodominant target antigen. There was no significant qualitative or quantitative difference in the HTLV-1-specific CD8(+) T cell response between the 2 groups. Virus-specific CD8(+) T cell frequency alone does not indicate the effectiveness of the cytotoxic T lymphocyte response in controlling provirus load at equilibrium.</description><subject>Biological and medical sciences</subject><subject>Carrier State - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HTLV-I Infections - immunology</subject><subject>HTLV-I Infections - virology</subject><subject>Human T-lymphotropic virus 1 - immunology</subject><subject>Humans</subject><subject>Immunodominant Epitopes - immunology</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Paraparesis, Tropical Spastic - immunology</subject><subject>Peptides - immunology</subject><subject>Virology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1LwzAUhoMobk79CRIERZFqTtKmqXcyPyYMvJneljQ9ZZn9MlmF_ns7NlC8OhfneV9eHkJOgd0CU_Iu5EwJvkfGEIk4kBLEPhkzxnkAKklG5Mj7FWMsFDI-JCOIQEEUqzH5nHWVrumCGixLWvZVu2zWrmmtod_WdZ5ezRbzj2u67lsMIPAtGlsMz-mjutmG_D19dvjVYW16quuc2qrq6iZvKlvr2iBdWnTamWV_TA4KXXo82d0JeX9-Wkxnwfzt5XX6MA-MkOE6MDoLQ-AGVJxgxrJCMJ1lQmNiMJdGxpzHmgkZAWZcMZC5YIghYBihKXIjJuRy29u6Ztjl12ll_WaqrrHpfBrzQYQEGMDzf-Cq6Vw9bEs5FwlAJNlvm3GN9w6LtHW20q5PgaUb9-nW_QCe7dq6rML8F9vJHoCLHaC90WXhBj3W_-GSKIkTJX4Ab42J7w</recordid><startdate>20040615</startdate><enddate>20040615</enddate><creator>GOON, Peter K. 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Psychology</topic><topic>HTLV-I Infections - immunology</topic><topic>HTLV-I Infections - virology</topic><topic>Human T-lymphotropic virus 1 - immunology</topic><topic>Humans</topic><topic>Immunodominant Epitopes - immunology</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Paraparesis, Tropical Spastic - immunology</topic><topic>Peptides - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOON, Peter K. C</creatorcontrib><creatorcontrib>BIANCARDI, Alix</creatorcontrib><creatorcontrib>BANGHAM, Charles R. 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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Biological and medical sciences Carrier State - immunology CD8-Positive T-Lymphocytes - immunology Epitopes, T-Lymphocyte - immunology Fundamental and applied biological sciences. Psychology HTLV-I Infections - immunology HTLV-I Infections - virology Human T-lymphotropic virus 1 - immunology Humans Immunodominant Epitopes - immunology Infectious diseases Interferon-gamma - biosynthesis Medical sciences Microbiology Miscellaneous Paraparesis, Tropical Spastic - immunology Peptides - immunology Virology |
| title | Human T cell lymphotropic virus (HTLV) type-1-specific CD8+T cells: Frequency and immunodominance hierarchy |
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