15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives

Graphic A novel series of 15-fluoro prostaglandins with phenoxy termination of the ω-chain was synthesized and evaluated for binding and functional activation of the prostaglandin FP receptor in vitro and for side effect potential and topical ocular hypotensive efficacy in vivo. Compounds with the 1...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2004-07, Vol.12 (13), p.3451-3469
Hauptverfasser:	Klimko, Peter, Hellberg, Mark, McLaughlin, Marsha, Sharif, Najam, Severns, Bryon, Williams, Gary, Haggard, Karen, Liao, John
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Fluoro prostaglandin Administration, Topical Animals Biological and medical sciences Cats Eye Fluorides - chemistry Glaucoma Haplorhini Medical sciences Molecular Structure Ocular Hypotension - drug therapy Pharmacology. Drug treatments Prostaglandins - chemical synthesis Prostaglandins - chemistry Prostaglandins - metabolism Prostaglandins - pharmacology Rabbits Receptors, Prostaglandin - agonists Receptors, Prostaglandin - chemistry Receptors, Prostaglandin - metabolism
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