The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Wnt signals control decisive steps in development and can induce the formation of tumors. Canonical Wnt signals control the formation of the embryonic axis, and are mediated by stabilization and interaction of beta-catenin with Lef/Tcf transcription factors. An alternative branch of the Wnt pathway...

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Veröffentlicht in:	Genes & development 2002-08, Vol.16 (16), p.2073-2084
Hauptverfasser:	Schwarz-Romond, Thomas, Asbrand, Christian, Bakkers, Jeroen, Kühl, Michael, Schaeffer, Hans-Joerg, Huelsken, Jörg, Behrens, Jürgen, Hammerschmidt, Matthias, Birchmeier, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankyrins - chemistry Axin Protein beta Catenin Blotting, Western Casein Kinases Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism DNA, Complementary - metabolism Drosophila Gene Expression Regulation, Developmental Intracellular Signaling Peptides and Proteins Mice Models, Biological Models, Genetic Phosphorylation Plasmids - metabolism Precipitin Tests Protein Binding Protein Kinases - metabolism Protein Kinases - physiology Protein Structure, Tertiary Proto-Oncogene Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Signal Transduction Time Factors Trans-Activators - metabolism Two-Hybrid System Techniques Wnt Proteins Xenopus Xenopus Proteins - biosynthesis Xenopus Proteins - metabolism Zebrafish Zebrafish Proteins - biosynthesis Zebrafish Proteins - chemistry
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