Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1
The highly homologous genes NIPSNAP3 and NIPSNAP4, with 87% amino acid identity, are members of the NIPSNAP family with putative roles in vesicular trafficking. NIPSNAP3 mRNA and NIPSNAP4 mRNA and protein were detected in multiple tissues and cells at varying degrees. Interestingly, NIPSNAP3 is most...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2004-06, Vol.83 (6), p.1116-1124 |
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| creator | BUECHLER, Christa BODZIOCH, Marek DEMBINSKA-KIEC, Aldona SCHMITZ, Gerd SALIM MAA BARED SIGRUENER, Alexander BOETTCHER, Alfred LAPICKA-BODZIOCH, Katarzyna ASLANIDIS, Charalampos DUONG, Chinh Quoc GRANDL, Margot LANGMANN, Thomas |
| description | The highly homologous genes NIPSNAP3 and NIPSNAP4, with 87% amino acid identity, are members of the NIPSNAP family with putative roles in vesicular trafficking. NIPSNAP3 mRNA and NIPSNAP4 mRNA and protein were detected in multiple tissues and cells at varying degrees. Interestingly, NIPSNAP3 is most highly expressed in skeletal muscle, where NIPSNAP4 has a low mRNA abundance. NIPSNAP4 was found associated with membranes and partly localized in rafts. The ubiquitous expression of the highly conserved NIPSNAPs and their association with membranes further support an important cellular function of these proteins probably linked to vesicular trafficking. The NIPSNAP3 and NIPSNAP4 genes are located in close proximity to the 3' end of the ATP-binding cassette transporter A1 (ABCA1), whose mutations cause familial high-density lipoprotein deficiency syndromes. The adjacent genomic location and the finding that ABCA1 is a regulator of vesicular trafficking may indicate a functional relation of these proteins, even though NIPSNAP4 does not interact directly with ABCA1 nor is its expression altered in cells with mutated ABCA1. |
| doi_str_mv | 10.1016/j.ygeno.2003.12.011 |
| format | Article |
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NIPSNAP3 mRNA and NIPSNAP4 mRNA and protein were detected in multiple tissues and cells at varying degrees. Interestingly, NIPSNAP3 is most highly expressed in skeletal muscle, where NIPSNAP4 has a low mRNA abundance. NIPSNAP4 was found associated with membranes and partly localized in rafts. The ubiquitous expression of the highly conserved NIPSNAPs and their association with membranes further support an important cellular function of these proteins probably linked to vesicular trafficking. The NIPSNAP3 and NIPSNAP4 genes are located in close proximity to the 3' end of the ATP-binding cassette transporter A1 (ABCA1), whose mutations cause familial high-density lipoprotein deficiency syndromes. The adjacent genomic location and the finding that ABCA1 is a regulator of vesicular trafficking may indicate a functional relation of these proteins, even though NIPSNAP4 does not interact directly with ABCA1 nor is its expression altered in cells with mutated ABCA1.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/j.ygeno.2003.12.011</identifier><identifier>PMID: 15177564</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Amino Acid Sequence ; Animals ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Sub-Family B Member 2 ; ATP-Binding Cassette Transporters - genetics ; Biological and medical sciences ; Caco-2 Cells ; CHO Cells ; Chromosome Mapping ; Chromosomes, Human, Pair 9 - genetics ; Cricetinae ; Cricetulus ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Genetics of eukaryotes. Biological and molecular evolution ; HT29 Cells ; Humans ; Membrane Microdomains - metabolism ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Polyethylene Glycols - chemistry ; Proteins - genetics ; Proteins - metabolism ; Sequence Alignment ; Sequence Analysis, Protein ; Tangier Disease - genetics ; Transport Vesicles - physiology ; Vesicular Transport Proteins</subject><ispartof>Genomics (San Diego, Calif.), 2004-06, Vol.83 (6), p.1116-1124</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-1c04b5655f87534b41fe474c6e33efde236ca235f2ab02995ca0701a6ea4eea13</citedby><cites>FETCH-LOGICAL-c428t-1c04b5655f87534b41fe474c6e33efde236ca235f2ab02995ca0701a6ea4eea13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15778586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15177564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BUECHLER, Christa</creatorcontrib><creatorcontrib>BODZIOCH, Marek</creatorcontrib><creatorcontrib>DEMBINSKA-KIEC, Aldona</creatorcontrib><creatorcontrib>SCHMITZ, Gerd</creatorcontrib><creatorcontrib>SALIM MAA BARED</creatorcontrib><creatorcontrib>SIGRUENER, Alexander</creatorcontrib><creatorcontrib>BOETTCHER, Alfred</creatorcontrib><creatorcontrib>LAPICKA-BODZIOCH, Katarzyna</creatorcontrib><creatorcontrib>ASLANIDIS, Charalampos</creatorcontrib><creatorcontrib>DUONG, Chinh Quoc</creatorcontrib><creatorcontrib>GRANDL, Margot</creatorcontrib><creatorcontrib>LANGMANN, Thomas</creatorcontrib><title>Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>The highly homologous genes NIPSNAP3 and NIPSNAP4, with 87% amino acid identity, are members of the NIPSNAP family with putative roles in vesicular trafficking. 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The adjacent genomic location and the finding that ABCA1 is a regulator of vesicular trafficking may indicate a functional relation of these proteins, even though NIPSNAP4 does not interact directly with ABCA1 nor is its expression altered in cells with mutated ABCA1.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>ATP Binding Cassette Transporter 1</subject><subject>ATP-Binding Cassette Sub-Family B Member 2</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>Biological and medical sciences</subject><subject>Caco-2 Cells</subject><subject>CHO Cells</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Membrane Microdomains - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, Protein</subject><subject>Tangier Disease - genetics</subject><subject>Transport Vesicles - physiology</subject><subject>Vesicular Transport Proteins</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEokvhCZCQL_REgv_He1xVBSpVZSXK2XKcya5XiR1ir9Q8Ey-J00aCGydr5N988818RfGe4IpgIj-fqvkAPlQUY1YRWmFCXhQbgtW2VJLLl8UGK6XKWnB2UbyJ8YQx3jJFXxcXRJC6FpJvit83j-MEMbrg0WhSgskj41s0mS4hE2OwzqTlM3To_nb_4363Z0_AWvBP6OgOx35GxzCEPhzCOaJxCgmcjwi8DS20qJlRtgoROY9sHyIsyKMbXJpRCigdAe0e9mXjfOv8Adk8GLIXlCbj4ximbAvtyNviVWf6CO_W97L4-eXm4fpbeff96-317q60nKpUEot5I6QQnaoF4w0nHfCaWwmMQdcCZdIaykRHTYPpdiuswTUmRoLhAIawy-LqWTeb_HWGmPTgooW-Nx7yerpeLo6p_C9IFBaSiW0G2TNopxDjBJ0eJzeYadYE6yVMfdJPYepFWhOqc5i568Mqf24GaP_2rOll4OMKmGhN3-VrWRf_4epaCSXZH_tuq1E</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>BUECHLER, Christa</creator><creator>BODZIOCH, Marek</creator><creator>DEMBINSKA-KIEC, Aldona</creator><creator>SCHMITZ, Gerd</creator><creator>SALIM MAA BARED</creator><creator>SIGRUENER, Alexander</creator><creator>BOETTCHER, Alfred</creator><creator>LAPICKA-BODZIOCH, Katarzyna</creator><creator>ASLANIDIS, Charalampos</creator><creator>DUONG, Chinh Quoc</creator><creator>GRANDL, Margot</creator><creator>LANGMANN, Thomas</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1</title><author>BUECHLER, Christa ; BODZIOCH, Marek ; DEMBINSKA-KIEC, Aldona ; SCHMITZ, Gerd ; SALIM MAA BARED ; SIGRUENER, Alexander ; BOETTCHER, Alfred ; LAPICKA-BODZIOCH, Katarzyna ; ASLANIDIS, Charalampos ; DUONG, Chinh Quoc ; GRANDL, Margot ; LANGMANN, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-1c04b5655f87534b41fe474c6e33efde236ca235f2ab02995ca0701a6ea4eea13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ATP Binding Cassette Transporter 1</topic><topic>ATP-Binding Cassette Sub-Family B Member 2</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>Biological and medical sciences</topic><topic>Caco-2 Cells</topic><topic>CHO Cells</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Membrane Microdomains - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, Protein</topic><topic>Tangier Disease - genetics</topic><topic>Transport Vesicles - physiology</topic><topic>Vesicular Transport Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUECHLER, Christa</creatorcontrib><creatorcontrib>BODZIOCH, Marek</creatorcontrib><creatorcontrib>DEMBINSKA-KIEC, Aldona</creatorcontrib><creatorcontrib>SCHMITZ, Gerd</creatorcontrib><creatorcontrib>SALIM MAA BARED</creatorcontrib><creatorcontrib>SIGRUENER, Alexander</creatorcontrib><creatorcontrib>BOETTCHER, Alfred</creatorcontrib><creatorcontrib>LAPICKA-BODZIOCH, Katarzyna</creatorcontrib><creatorcontrib>ASLANIDIS, Charalampos</creatorcontrib><creatorcontrib>DUONG, Chinh Quoc</creatorcontrib><creatorcontrib>GRANDL, Margot</creatorcontrib><creatorcontrib>LANGMANN, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUECHLER, Christa</au><au>BODZIOCH, Marek</au><au>DEMBINSKA-KIEC, Aldona</au><au>SCHMITZ, Gerd</au><au>SALIM MAA BARED</au><au>SIGRUENER, Alexander</au><au>BOETTCHER, Alfred</au><au>LAPICKA-BODZIOCH, Katarzyna</au><au>ASLANIDIS, Charalampos</au><au>DUONG, Chinh Quoc</au><au>GRANDL, Margot</au><au>LANGMANN, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>83</volume><issue>6</issue><spage>1116</spage><epage>1124</epage><pages>1116-1124</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The highly homologous genes NIPSNAP3 and NIPSNAP4, with 87% amino acid identity, are members of the NIPSNAP family with putative roles in vesicular trafficking. NIPSNAP3 mRNA and NIPSNAP4 mRNA and protein were detected in multiple tissues and cells at varying degrees. Interestingly, NIPSNAP3 is most highly expressed in skeletal muscle, where NIPSNAP4 has a low mRNA abundance. NIPSNAP4 was found associated with membranes and partly localized in rafts. The ubiquitous expression of the highly conserved NIPSNAPs and their association with membranes further support an important cellular function of these proteins probably linked to vesicular trafficking. The NIPSNAP3 and NIPSNAP4 genes are located in close proximity to the 3' end of the ATP-binding cassette transporter A1 (ABCA1), whose mutations cause familial high-density lipoprotein deficiency syndromes. The adjacent genomic location and the finding that ABCA1 is a regulator of vesicular trafficking may indicate a functional relation of these proteins, even though NIPSNAP4 does not interact directly with ABCA1 nor is its expression altered in cells with mutated ABCA1.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>15177564</pmid><doi>10.1016/j.ygeno.2003.12.011</doi><tpages>9</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals ATP Binding Cassette Transporter 1 ATP-Binding Cassette Sub-Family B Member 2 ATP-Binding Cassette Transporters - genetics Biological and medical sciences Caco-2 Cells CHO Cells Chromosome Mapping Chromosomes, Human, Pair 9 - genetics Cricetinae Cricetulus Fundamental and applied biological sciences. Psychology Genes. Genome Genetics of eukaryotes. Biological and molecular evolution HT29 Cells Humans Membrane Microdomains - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Polyethylene Glycols - chemistry Proteins - genetics Proteins - metabolism Sequence Alignment Sequence Analysis, Protein Tangier Disease - genetics Transport Vesicles - physiology Vesicular Transport Proteins |
| title | Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1 |
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