Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor

Analogues of 9-cis-retinoic acid incorporating an alicyclic ring between the C19 and C10 positions have been synthesized and evaluated as ligands for the RXRα nuclear receptor. The stereocontrolled synthesis of these configurationally constrained retinoids combines a Stille cross-coupling and the Wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2002-08, Vol.67 (17), p.5876-5882
Hauptverfasser:	Otero, M. Paz, Torrado, Alicia, Pazos, Yolanda, Sussman, Fredy, de Lera, Angel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Alitretinoin Animals Catalysis Chemistry Computer Simulation COS Cells - drug effects Exact sciences and technology Ligands Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Organic chemistry Palladium - chemistry Preparations and properties Receptors, Retinoic Acid Retinoid X Receptors Stereoisomerism Terpenoids Transcription Factors - pharmacology Tretinoin - chemical synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!