Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice

Glycogen synthase kinase-3β (GSK-3β) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3β[S9A]. Magnetic resonance imaging revealed a reduced volume...

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Veröffentlicht in:	Neuroscience 2002-01, Vol.113 (4), p.797-808
Hauptverfasser:	Spittaels, K, Van den Haute, C, Van Dorpe, J, Terwel, D, Vandezande, K, Lasrado, R, Bruynseels, K, Irizarry, M, Verhoye, M, Van Lint, J, R. Vandenheede, J, Ashton, D, Mercken, M, Loos, R, Hyman, B, Van der Linden, A, Geerts, H, Van Leuven, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Brain - enzymology Brain - growth & development Brain - pathology Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Glycogen Synthase Kinase 3 - biosynthesis Glycogen Synthase Kinase 3 - genetics glycogen synthase kinase-3β Humans Male Mice Mice, Inbred C57BL Mice, Transgenic microcephaly microtubule-associated protein 2 Neurons - enzymology Neurons - pathology Psychomotor Performance - physiology transgenic mice Vertebrates: nervous system and sense organs
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