NMDA receptor antagonists impair motor performance in immature rats

Antagonists of NMDA receptors are excellent anticonvulsants in adult animals but serious side effects prevent their clinical use. The effects of two antagonists on motor performance were studied to find out if they develop in parallel with previously described anticonvulsant action. Motor performanc...

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Veröffentlicht in:	Psychopharmacologia 2002-08, Vol.162 (4), p.364-372
Hauptverfasser:	MIKULECKA, A, MARES, P
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - analogs & derivatives 2-Amino-5-phosphonovalerate - pharmacology Age Age Factors Animals Animals, Newborn Anticonvulsants Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Biological and medical sciences Convulsions & seizures Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug dosages Excitatory Amino Acid Antagonists - pharmacology Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Time Factors
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