Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors

In addition to antiviral effects, Type I interferons (IFN) have potent antiproliferative and immunomodulatory activities. Because of these properties IFNs have been evaluated as therapeutics for the treatment of a number of human diseases, including cancer. Currently, IFNs have been shown to be effi...

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Veröffentlicht in:	International journal of cancer 2004-08, Vol.111 (1), p.32-42
Hauptverfasser:	Wagner, T. Charis, Velichko, Sharlene, Chesney, Steven K., Biroc, Sandra, Harde, Dean, Vogel, David, Croze, Ed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology antiproliferation Apoptosis Biological and medical sciences cancer Caspase 3 Caspases - pharmacology Cell Line, Tumor DNA Damage Female Gene Expression Regulation, Neoplastic gene therapy Genetic Therapy - methods Humans Immunotherapy interferon interferon receptor Interferons - pharmacology Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Receptor, Interferon alpha-beta Receptors, Interferon - biosynthesis Receptors, Interferon - physiology Signal Transduction Transfection Transplantation, Heterologous
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