Nitric oxide and wound repair: role of cytokines?
Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial...
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| Veröffentlicht in: | Nitric Oxide 2002-08, Vol.7 (1), p.1-10 |
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| creator | Schwentker, Ann Vodovotz, Yoram Weller, Richard Billiar, Timothy R |
| description | Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial NOS) and iNOS (NOS2; inducible NOS), respectively. Indeed, pharmacological inhibition or gene deletion of these enzymes impairs wound healing. The wound healing mechanisms that are triggered by NO appear to be diverse, involving inflammation, angiogenesis, and cell proliferation. All of these processes are controlled by defined cytokine cascades; in many cases, NO appears to modulate these cytokines. In this review, we summarize the history and present state of research on the role of NO in wound healing within the framework of modulation of cytokines. |
| doi_str_mv | 10.1016/S1089-8603(02)00002-2 |
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| language | eng |
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| subjects | Animals Cytokines - physiology Extracellular Matrix - metabolism Humans Inflammation - immunology Inflammation - pathology Keratinocytes - cytology MCP-1 Neovascularization, Physiologic Nitric oxide Nitric Oxide - physiology TGF-β VEGF Wound healing Wound Healing - physiology |
| title | Nitric oxide and wound repair: role of cytokines? |
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