Bradykinin Contributes to the Systemic Hemodynamic Effects of Chronic Angiotensin-Converting Enzyme Inhibition in Patients With Heart Failure

BACKGROUND—Bradykinin is an endogenous vasodilator that may contribute to the systemic effects of angiotensin-converting enzyme (ACE) inhibitor therapy. Using B9340, a bradykinin receptor antagonist, we determined the contribution of bradykinin to the systemic hemodynamic effects of long-term ACE in...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-06, Vol.24 (6), p.1043-1048
Hauptverfasser:	Cruden, Nicholas L.M, Witherow, Fraser N, Webb, David J, Fox, Keith A.A, Newby, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin II - blood Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin - physiology Bradykinin - therapeutic use Bradykinin Receptor Antagonists Cardiac Output - drug effects Cardiology. Vascular system Cross-Over Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Enalapril - pharmacology Enalapril - therapeutic use Female Forearm - blood supply Heart Failure - blood Heart Failure - drug therapy Heart Failure - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Hemodynamics - physiology Humans Losartan - pharmacology Losartan - therapeutic use Male Medical sciences Middle Aged Peptidyl-Dipeptidase A - blood Regional Blood Flow - drug effects Vasodilation - drug effects
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