Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum
The present study focused on the effect of a series of extracts and two 5,6,7-trioxygenated coumarins isolated from Pterocaulon polystachyum on the proliferation and differentiation of human promonocytic U-937 cells. The petroleum ether extract was the only extract that significantly reduced cell pr...
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| Veröffentlicht in: | Cancer letters 2004-07, Vol.210 (2), p.179-188 |
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| container_title | Cancer letters |
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| creator | Eugenia Riveiro, Marı́a Shayo, Carina Monczor, Federico Fernández, Natalia Baldi, Alberto De Kimpe, Norbert Rossi, Javier Debenedetti, Silvia Davio, Carlos |
| description | The present study focused on the effect of a series of extracts and two 5,6,7-trioxygenated coumarins isolated from
Pterocaulon polystachyum on the proliferation and differentiation of human promonocytic U-937 cells. The petroleum ether extract was the only extract that significantly reduced cell proliferation and induced cell differentiation. Treatment with pure 5-methoxy-6,7-methylenedioxycoumarin (C1) and 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C2), present in the petroleum ether extract, showed a time and concentration-dependent inhibition on cell proliferation. In addition, the coumarin derivatives were also able to induce CD88 functionality and NBT reduction, markers of monocytic cell differentiation.
These results suggest that C1 and C2 might have a potential therapeutic role in the management of leukemia. |
| doi_str_mv | 10.1016/j.canlet.2004.03.015 |
| format | Article |
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Pterocaulon polystachyum on the proliferation and differentiation of human promonocytic U-937 cells. The petroleum ether extract was the only extract that significantly reduced cell proliferation and induced cell differentiation. Treatment with pure 5-methoxy-6,7-methylenedioxycoumarin (C1) and 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C2), present in the petroleum ether extract, showed a time and concentration-dependent inhibition on cell proliferation. In addition, the coumarin derivatives were also able to induce CD88 functionality and NBT reduction, markers of monocytic cell differentiation.
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Pterocaulon polystachyum on the proliferation and differentiation of human promonocytic U-937 cells. The petroleum ether extract was the only extract that significantly reduced cell proliferation and induced cell differentiation. Treatment with pure 5-methoxy-6,7-methylenedioxycoumarin (C1) and 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C2), present in the petroleum ether extract, showed a time and concentration-dependent inhibition on cell proliferation. In addition, the coumarin derivatives were also able to induce CD88 functionality and NBT reduction, markers of monocytic cell differentiation.
These results suggest that C1 and C2 might have a potential therapeutic role in the management of leukemia.</description><subject>5-oxygenated-6,7-methylenedioxycoumarins</subject><subject>Apoptosis</subject><subject>Asteraceae - chemistry</subject><subject>CD88</subject><subject>Cell adhesion & migration</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell growth</subject><subject>Coumarins - chemistry</subject><subject>Coumarins - isolation & purification</subject><subject>Coumarins - pharmacology</subject><subject>Humans</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Leukemia, Promyelocytic, Acute - pathology</subject><subject>Monocytes - physiology</subject><subject>Natural products</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Pterocaulon polystachyum</subject><subject>Studies</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoTjv6BiIBwZXVJpVKUrURZPBnYEAXzjqkkhs7bVXSJimxHsG3Nv0DggtXgZvvnOTcg9BzSraUUPFmvzU6TFC2LSHdlrAtofwB2tBeto0cevIQbQgjXcN6xq_Qk5z3hBDeSf4YXVFO65SxDfp9G-xiio8BR4cNTBO23jlIEIrXp7kPeLfMOuAJlu8we43vm4HJE5zxuGLexF_rNwi6gG3Ea9nMUHbrBAGsrzcmVnXyIWOX4oy_FEjR6GWq1oc4rblos1uX-Sl65PSU4dnlvEb3H95_vfnU3H3-eHvz7q4xrBelGZweuQBunXRGtsPgxCiEtlLYtm1dTSh65qQY7QhsbAc6DKIXpm2F1tKNHbtGr86-hxR_LJCLmn0-ZtEB4pKVrArJKa_gy3_AfVxSqH9TlBPOhGQDqVR3pkyKOSdw6pB8zbsqStSxKLVX56LUsShFmCIn8xcX82Wcwf4VXZqpwNszAHUXPz0klY2HYOpOE5iibPT_f-EPsVCoBw</recordid><startdate>20040716</startdate><enddate>20040716</enddate><creator>Eugenia Riveiro, Marı́a</creator><creator>Shayo, Carina</creator><creator>Monczor, Federico</creator><creator>Fernández, Natalia</creator><creator>Baldi, Alberto</creator><creator>De Kimpe, Norbert</creator><creator>Rossi, Javier</creator><creator>Debenedetti, Silvia</creator><creator>Davio, Carlos</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040716</creationdate><title>Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum</title><author>Eugenia Riveiro, Marı́a ; 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| ispartof | Cancer letters, 2004-07, Vol.210 (2), p.179-188 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-oxygenated-6,7-methylenedioxycoumarins Apoptosis Asteraceae - chemistry CD88 Cell adhesion & migration Cell differentiation Cell Differentiation - drug effects Cell growth Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Humans Kinases Leukemia Leukemia, Promyelocytic, Acute - pathology Monocytes - physiology Natural products Plant Extracts - chemistry Plant Extracts - pharmacology Pterocaulon polystachyum Studies Tumor Cells, Cultured |
| title | Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum |
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