Resistance to Neointimal Hyperplasia and Fatty Streak Formation in Mice With Adrenomedullin Overexpression

OBJECTIVE—Several in vitro studies have implicated that adrenomedullin (AM) plays an important role in the pathogenesis of vascular injury and fatty streak formation. To test this possibility in vivo, we evaluated 2 experimental models using transgenic mice overexpressing AM in a vessel-selective ma...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2002-08, Vol.22 (8), p.1310-1315
Hauptverfasser:	Imai, Yasushi, Shindo, Takayuki, Maemura, Koji, Sata, Masataka, Saito, Yuichiro, Kurihara, Yukiko, Akishita, Masahiro, Osuga, Junichi, Ishibashi, Shun, Tobe, Kazuyuki, Morita, Hiroyuki, Oh-hashi, Yoshio, Suzuki, Toru, Maekawa, Hiromitsu, Kangawa, Kenji, Minamino, Naoto, Yazaki, Yoshio, Nagai, Ryozo, Kurihara, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adrenomedullin Animals Apolipoproteins E - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcitonin Gene-Related Peptide - pharmacology Cardiology. Vascular system Femoral Artery - metabolism Femoral Artery - pathology Hydralazine - pharmacology Hyperplasia - prevention & control Medical sciences Mice Mice, Knockout Mice, Transgenic NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Peptide Fragments - pharmacology Peptides - metabolism Tunica Intima - drug effects Tunica Intima - metabolism Tunica Intima - pathology
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