Combination of ziprasidone and clozapine in treatment‐resistant schizophrenia
In cases of treatment‐resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past. We report the difficult treatment of a 28‐year‐old s...
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| Veröffentlicht in: | Human psychopharmacology 2004-06, Vol.19 (4), p.271-273 |
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| container_title | Human psychopharmacology |
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| creator | Zink, M. Mase, E. Dressing, H. |
| description | In cases of treatment‐resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past.
We report the difficult treatment of a 28‐year‐old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.
The reported combination is a promising option in cases of treatment‐resistant schizophrenia and should be further evaluated in prospective studies. Copyright © 2004 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/hup.580 |
| format | Article |
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We report the difficult treatment of a 28‐year‐old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.
The reported combination is a promising option in cases of treatment‐resistant schizophrenia and should be further evaluated in prospective studies. Copyright © 2004 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6222</identifier><identifier>EISSN: 1099-1077</identifier><identifier>DOI: 10.1002/hup.580</identifier><identifier>PMID: 15181656</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - therapeutic use ; clozapine ; Clozapine - administration & dosage ; Clozapine - therapeutic use ; Drug Resistance ; Drug Therapy, Combination ; Female ; Humans ; Piperazines - administration & dosage ; Piperazines - therapeutic use ; schizophrenia ; Schizophrenia - drug therapy ; Thiazoles - administration & dosage ; Thiazoles - therapeutic use ; Treatment Outcome ; treatment resistance ; ziprasidone</subject><ispartof>Human psychopharmacology, 2004-06, Vol.19 (4), p.271-273</ispartof><rights>Copyright © 2004 John Wiley & Sons, Ltd.</rights><rights>Copyright 2004 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3130-8ccf417de8d380b4876e47aff218f407619b5ec50d2604cf0a8018bec0d7415e3</citedby><cites>FETCH-LOGICAL-c3130-8ccf417de8d380b4876e47aff218f407619b5ec50d2604cf0a8018bec0d7415e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhup.580$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhup.580$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15181656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zink, M.</creatorcontrib><creatorcontrib>Mase, E.</creatorcontrib><creatorcontrib>Dressing, H.</creatorcontrib><title>Combination of ziprasidone and clozapine in treatment‐resistant schizophrenia</title><title>Human psychopharmacology</title><addtitle>Hum Psychopharmacol</addtitle><description>In cases of treatment‐resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past.
We report the difficult treatment of a 28‐year‐old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.
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We report the difficult treatment of a 28‐year‐old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.
The reported combination is a promising option in cases of treatment‐resistant schizophrenia and should be further evaluated in prospective studies. Copyright © 2004 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15181656</pmid><doi>10.1002/hup.580</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-6222 |
| ispartof | Human psychopharmacology, 2004-06, Vol.19 (4), p.271-273 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antipsychotic Agents - administration & dosage Antipsychotic Agents - therapeutic use clozapine Clozapine - administration & dosage Clozapine - therapeutic use Drug Resistance Drug Therapy, Combination Female Humans Piperazines - administration & dosage Piperazines - therapeutic use schizophrenia Schizophrenia - drug therapy Thiazoles - administration & dosage Thiazoles - therapeutic use Treatment Outcome treatment resistance ziprasidone |
| title | Combination of ziprasidone and clozapine in treatment‐resistant schizophrenia |
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