Pathologic staging of melanoma
The American Joint Committee on Cancer (AJCC) recently launched a new staging system for cutaneous melanoma that was based on clinical experience with a large number of patients treated in major centers worldwide. As this system includes various histopathologic parameters of the primary melanoma and...
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| Veröffentlicht in: | Seminars in oncology 2002-08, Vol.29 (4), p.370-381 |
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| container_title | Seminars in oncology |
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| creator | Ruiter, Dirk J. Spatz, Alain van den Oord, Joost J. Cook, Martin G. |
| description | The American Joint Committee on Cancer (AJCC) recently launched a new staging system for cutaneous melanoma that was based on clinical experience with a large number of patients treated in major centers worldwide. As this system includes various histopathologic parameters of the primary melanoma and of melanoma metastasis, including micrometastases in the sentinel lymph node (SLN), they are discussed here. Special attention is given to ulceration of the primary tumor, because it remains a dominant prognostic parameter in addition to tumor thickness. Molecular markers that may reflect aggressive behavior of the primary melanoma also are described. Finally, pathologic examination of SLNs is addressed with emphasis on the efficacy of various microstaging approaches. Semin Oncol 29:370-381. Copyright 2002, Elsevier Science (USA). All rights reserved. |
| doi_str_mv | 10.1053/sonc.2002.34116 |
| format | Article |
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As this system includes various histopathologic parameters of the primary melanoma and of melanoma metastasis, including micrometastases in the sentinel lymph node (SLN), they are discussed here. Special attention is given to ulceration of the primary tumor, because it remains a dominant prognostic parameter in addition to tumor thickness. Molecular markers that may reflect aggressive behavior of the primary melanoma also are described. Finally, pathologic examination of SLNs is addressed with emphasis on the efficacy of various microstaging approaches. Semin Oncol 29:370-381. Copyright 2002, Elsevier Science (USA). 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As this system includes various histopathologic parameters of the primary melanoma and of melanoma metastasis, including micrometastases in the sentinel lymph node (SLN), they are discussed here. Special attention is given to ulceration of the primary tumor, because it remains a dominant prognostic parameter in addition to tumor thickness. Molecular markers that may reflect aggressive behavior of the primary melanoma also are described. Finally, pathologic examination of SLNs is addressed with emphasis on the efficacy of various microstaging approaches. Semin Oncol 29:370-381. Copyright 2002, Elsevier Science (USA). All rights reserved.</description><subject>Antibodies</subject><subject>Biomarkers, Tumor - analysis</subject><subject>DNA, Neoplasm - analysis</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Melanoma - pathology</subject><subject>Melanoma - secondary</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk Factors</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Ulcer - pathology</subject><issn>0093-7754</issn><issn>1532-8708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOAzEQRS0EIiFQ00Wp6DYZe_blEkW8pEhQQG05Y28w2l0He4PE3-OQSFRUM8WZqzuHsWsOcw4FLqLvaS4AxBxzzssTNuYFiqyuoD5lYwCJWVUV-YhdxPiRMF4Jcc5GPC2Q5zBm0xc9vPvWbxzN4qA3rt_MfDPrbKt73-lLdtboNtqr45ywt_u71-Vjtnp-eFrerjLCHIesKBF1mSIl1iC0NBYIDDVmjZzWKAk1gE2tNPKcV2RqqTU1ukAJNW84TtjNIXcb_OfOxkF1LpJtUwvrd1FVXMqykCKBiwNIwccYbKO2wXU6fCsOaq9E7ZWovRL1qyRdTI_Ru3VnzR9_dJAAeQBsevDL2aAiOduTNS5YGpTx7t_wHxgYbl0</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Ruiter, Dirk J.</creator><creator>Spatz, Alain</creator><creator>van den Oord, Joost J.</creator><creator>Cook, Martin G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Pathologic staging of melanoma</title><author>Ruiter, Dirk J. ; Spatz, Alain ; van den Oord, Joost J. ; Cook, Martin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-5633a670493802a9de0c0dcfdb31cb39c3a00e870a31417cd89aacfa539081f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antibodies</topic><topic>Biomarkers, Tumor - analysis</topic><topic>DNA, Neoplasm - analysis</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Melanoma - pathology</topic><topic>Melanoma - secondary</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Ulcer - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiter, Dirk J.</creatorcontrib><creatorcontrib>Spatz, Alain</creatorcontrib><creatorcontrib>van den Oord, Joost J.</creatorcontrib><creatorcontrib>Cook, Martin G.</creatorcontrib><creatorcontrib>Pathology Committee of the European Organization Research and Treatment of Cancer (EORTC) Melanoma Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiter, Dirk J.</au><au>Spatz, Alain</au><au>van den Oord, Joost J.</au><au>Cook, Martin G.</au><aucorp>Pathology Committee of the European Organization Research and Treatment of Cancer (EORTC) Melanoma Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathologic staging of melanoma</atitle><jtitle>Seminars in oncology</jtitle><addtitle>Semin Oncol</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>29</volume><issue>4</issue><spage>370</spage><epage>381</epage><pages>370-381</pages><issn>0093-7754</issn><eissn>1532-8708</eissn><abstract>The American Joint Committee on Cancer (AJCC) recently launched a new staging system for cutaneous melanoma that was based on clinical experience with a large number of patients treated in major centers worldwide. 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| ispartof | Seminars in oncology, 2002-08, Vol.29 (4), p.370-381 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibodies Biomarkers, Tumor - analysis DNA, Neoplasm - analysis Humans Lymph Nodes - pathology Lymphatic Metastasis - pathology Melanoma - pathology Melanoma - secondary Neoplasm Proteins - analysis Neoplasm Staging Prognosis Reverse Transcriptase Polymerase Chain Reaction Risk Factors Sentinel Lymph Node Biopsy Skin Neoplasms - pathology Skin Ulcer - pathology |
| title | Pathologic staging of melanoma |
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