UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecan‐administered Japanese Patients with Cancer

Purpose A comprehensive haplotype analysis of UGT1A1 in the Japanese population was conducted, and the effects of these haplotypes were investigated with respect to UGT1A1‐related phenotypic parameters in patients with cancer who received irinotecan. Methods The UGT1A1 gene, including the enhancer,...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2004-06, Vol.75 (6), p.501-515
Hauptverfasser:	Sai, Kimie, Saeki, Mayumi, Saito, Yoshiro, Ozawa, Shogo, Katori, Noriko, Jinno, Hideto, Hasegawa, Ryuichi, Kaniwa, Nahoko, Sawada, Jun‐ichi, Komamura, Kazuo, Ueno, Kazuyuki, Kamakura, Shiro, Kitakaze, Masafumi, Kitamura, Yutaka, Kamatani, Naoyuki, Minami, Hironobu, Ohtsu, Atsushi, Shirao, Kuniaki, Yoshida, Teruhiko, Saijo, Nagahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bilirubin - blood Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - metabolism Female Genetic Linkage - genetics Glucuronides - genetics Glucuronides - metabolism Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Haplotypes - genetics Humans Japan Male Middle Aged Neoplasms - blood Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Polymorphism, Single Nucleotide - genetics
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