Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis
Multiple sclerosis, a primary autoimmune disease of the central nervous system has been characterized by the presence of the demyelinating lesions (plaques) in the CNS. To further understand the gene transcription status of the two most common lesions, chronic active and chronic inactive, we have pe...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2004-06, Vol.106 (3), p.223-229 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Mycko, Marcin P Papoian, Ruben Boschert, Ursula Raine, Cedric S Selmaj, Krzysztof W |
| description | Multiple sclerosis, a primary autoimmune disease of the central nervous system has been characterized by the presence of the demyelinating lesions (plaques) in the CNS. To further understand the gene transcription status of the two most common lesions, chronic active and chronic inactive, we have performed a cDNA microarray analysis of these two lesion type. Comparative analysis of differential gene expression of chronic active and inactive lesions have confirmed the existence of a significant difference in the transcriptional profiles of these two lesion types in both marginal and central areas. Different sets of genes were highlighted, including genes of inflammatory characteristics, apoptosis related and stress-induced, indicating their potential role in MS pathogenesis. |
| doi_str_mv | 10.1016/j.clineuro.2004.02.019 |
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To further understand the gene transcription status of the two most common lesions, chronic active and chronic inactive, we have performed a cDNA microarray analysis of these two lesion type. Comparative analysis of differential gene expression of chronic active and inactive lesions have confirmed the existence of a significant difference in the transcriptional profiles of these two lesion types in both marginal and central areas. Different sets of genes were highlighted, including genes of inflammatory characteristics, apoptosis related and stress-induced, indicating their potential role in MS pathogenesis.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2004.02.019</identifier><identifier>PMID: 15177772</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Brain - pathology ; Brain tissue ; Chronic active lesions ; Chronic silent lesions ; Differential gene expression ; DNA, Complementary - genetics ; Gene expression ; Gene Expression - genetics ; Gene Expression Profiling ; Gene Silencing ; Humans ; Medical research ; Medical sciences ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - pathology ; Neurology ; Neurosurgery ; Oligonucleotide Array Sequence Analysis - methods ; Pathogenesis ; Polymerase Chain Reaction ; RNA - genetics ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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To further understand the gene transcription status of the two most common lesions, chronic active and chronic inactive, we have performed a cDNA microarray analysis of these two lesion type. Comparative analysis of differential gene expression of chronic active and inactive lesions have confirmed the existence of a significant difference in the transcriptional profiles of these two lesion types in both marginal and central areas. Different sets of genes were highlighted, including genes of inflammatory characteristics, apoptosis related and stress-induced, indicating their potential role in MS pathogenesis.</description><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain tissue</subject><subject>Chronic active lesions</subject><subject>Chronic silent lesions</subject><subject>Differential gene expression</subject><subject>DNA, Complementary - genetics</subject><subject>Gene expression</subject><subject>Gene Expression - genetics</subject><subject>Gene Expression Profiling</subject><subject>Gene Silencing</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Multiple Sclerosis - pathology</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Pathogenesis</subject><subject>Polymerase Chain Reaction</subject><subject>RNA - genetics</subject><subject>Surgery (general aspects). 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| subjects | Biological and medical sciences Brain - pathology Brain tissue Chronic active lesions Chronic silent lesions Differential gene expression DNA, Complementary - genetics Gene expression Gene Expression - genetics Gene Expression Profiling Gene Silencing Humans Medical research Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neurology Neurosurgery Oligonucleotide Array Sequence Analysis - methods Pathogenesis Polymerase Chain Reaction RNA - genetics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Up-Regulation |
| title | Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis |
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