Comprehensive Determinant Mapping of the Hepatitis C-Specific CD8 Cell Repertoire Reveals Unpredicted Immune Hierarchy

While CD8 cells are thought to play an important role in the control hepatitis C infection, low frequencies of virus-specific cells and high numbers of potential determinants have made it challenging to obtain direct and comprehensive data regarding fine specificity and clonal size of the CD8 cells...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2002-06, Vol.103 (3), p.264-276
Hauptverfasser:	Anthony, Donald D., Valdez, Hernan, Post, Anthony B., Carlson, Nicole L., Heeger, Peter S., Lehmann, Paul V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences CD8-Positive T-Lymphocytes - immunology cellular cytokine ELISPOT Enzyme-Linked Immunosorbent Assay Epitope Mapping Epitopes, T-Lymphocyte - immunology Hepacivirus - immunology hepatitis C Hepatitis C - immunology HLA Antigens - immunology human Human viral diseases Humans immunity Immunodominant Epitopes - immunology Infectious diseases Interferon-gamma - biosynthesis Interferon-gamma - blood Interleukin-4 - biosynthesis Interleukin-4 - blood Interleukin-5 - biosynthesis Interleukin-5 - blood Medical sciences Peptide Library T cell Viral diseases Viral hepatitis
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