Decreased beta-cell proliferation impairs the adaptation to pregnancy in rats malnourished during perinatal life

We investigated the cellular mechanisms responsible for the inability of 8-month-old previously malnourished (PM) females to adapt their beta-cell mass during pregnancy. The evolution during pregnancy of beta-cell fraction, size and proliferation was studied. At day 21 of pregnancy beta-cell fractio...

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Veröffentlicht in:	Journal of endocrinology 2002-08, Vol.174 (2), p.215-223
Hauptverfasser:	Avril, I, Blondeau, B, Duchene, B, Czernichow, P, Breant, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Count Cell Division Cell Size Endocrine pancreas Female Fetal Growth Retardation - pathology Fundamental and applied biological sciences. Psychology Gestational Age Immunohistochemistry - methods Insulin - analysis Islets of Langerhans - chemistry Islets of Langerhans - metabolism Islets of Langerhans - pathology Models, Animal Morphology. Functional localizations Pancreas - pathology Pregnancy Prolactin - metabolism Rats Rats, Wistar Receptors, Prolactin - analysis Vertebrates: endocrinology
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