IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis
IL‐16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti‐HIV‐1 activities. We determined IL‐16 expression in human brain tissue with HIV‐1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL‐16. IL‐1...
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| Veröffentlicht in: | Neuropathology and applied neurobiology 2004-06, Vol.30 (3), p.233-242 |
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| creator | Zhao, M.-L. Si, Q. Lee, S. C. |
| description | IL‐16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti‐HIV‐1 activities. We determined IL‐16 expression in human brain tissue with HIV‐1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL‐16. IL‐16 immunoreactivity was particularly pronounced in microglial nodules. In vitro, human foetal microglia and not astrocytes produce IL‐16, and HIV‐1 infection up‐regulates microglial IL‐16 release in a Nef‐dependent manner. These results support the notion that, in the brain, IL‐16 is a macrophage‐lineage specific modulator of the inflammatory response and HIV‐1 expression. Recruitment of IL‐16+ T cells and microglia/macrophages may represent an innate response to HIV‐1 infection in the central nervous system that counterbalances viral stimulatory factors. |
| doi_str_mv | 10.1046/j.0305-1846.2003.00527.x |
| format | Article |
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C.</creatorcontrib><title>IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis</title><title>Neuropathology and applied neurobiology</title><addtitle>Neuropathol Appl Neurobiol</addtitle><description>IL‐16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti‐HIV‐1 activities. We determined IL‐16 expression in human brain tissue with HIV‐1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL‐16. IL‐16 immunoreactivity was particularly pronounced in microglial nodules. In vitro, human foetal microglia and not astrocytes produce IL‐16, and HIV‐1 infection up‐regulates microglial IL‐16 release in a Nef‐dependent manner. These results support the notion that, in the brain, IL‐16 is a macrophage‐lineage specific modulator of the inflammatory response and HIV‐1 expression. Recruitment of IL‐16+ T cells and microglia/macrophages may represent an innate response to HIV‐1 infection in the central nervous system that counterbalances viral stimulatory factors.</description><subject>AIDS Dementia Complex - genetics</subject><subject>AIDS Dementia Complex - metabolism</subject><subject>astrocyte</subject><subject>Astrocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cells, Cultured</subject><subject>chemokine</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Interleukin-16 - biosynthesis</subject><subject>Interleukin-16 - genetics</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Lymphocytes - metabolism</subject><subject>macrophage</subject><subject>Medical sciences</subject><subject>Microglia - metabolism</subject><subject>microglial nodule</subject><subject>Nef</subject><subject>Neurology</subject><subject>Paraffin Embedding</subject><subject>Stimulation, Chemical</subject><subject>T-Lymphocytes - metabolism</subject><subject>Tissue Fixation</subject><issn>0305-1846</issn><issn>1365-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlu2zAURYmiRe24_YVCm3Yn9XEQB6CbwIgdA4aDwE6zJCiKSuhoimij9t9Xio00u3TFB_DcNxyEIgwJBsZ_bhOgkMZYMp4QAJoApEQkhw9ojClPY6IUfETjV2iELkLYQk8Jrj6jEU6xSEGIMZouljHmkTu0nQvBN3Xk66g8Vu1jY487FyJT51Hlbdc8lN4Mn9eL3zGOXG1d-2hKv_PhC_pUmDK4r-d3gu5mV5vpdby8mS-ml8vYMk5FLNNMFpYwIrmRhgHBRiiWiYwqIxjJc2KhkI5JVtgMCM-kBaWkoTTDkFNMJ-jHqW_bNc97F3a68sG6sjS1a_ZBC6xUf336LoiFUgzD0FGewP6-EDpX6LbzlemOGoMeTOutHiTqQaIeTOsX0_rQR7-dZ-yzyuX_gme1PfD9DJhgTVl0prY-vOEkEEGh536duD--dMf_XkCvLld90cfjU9yHnTu8xk33pLmgItX3q7le3zK1uV9P9Yz-BbzEpeY</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Zhao, M.-L.</creator><creator>Si, Q.</creator><creator>Lee, S. C.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis</title><author>Zhao, M.-L. ; Si, Q. ; Lee, S. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-85b8fc24286a8a4021a794b7b39a742dd2c0f8e484fcb026b8c0998a33b10d313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>AIDS Dementia Complex - genetics</topic><topic>AIDS Dementia Complex - metabolism</topic><topic>astrocyte</topic><topic>Astrocytes - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Cells, Cultured</topic><topic>chemokine</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Interleukin-16 - biosynthesis</topic><topic>Interleukin-16 - genetics</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Lymphocytes - metabolism</topic><topic>macrophage</topic><topic>Medical sciences</topic><topic>Microglia - metabolism</topic><topic>microglial nodule</topic><topic>Nef</topic><topic>Neurology</topic><topic>Paraffin Embedding</topic><topic>Stimulation, Chemical</topic><topic>T-Lymphocytes - metabolism</topic><topic>Tissue Fixation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, M.-L.</creatorcontrib><creatorcontrib>Si, Q.</creatorcontrib><creatorcontrib>Lee, S. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropathology and applied neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, M.-L.</au><au>Si, Q.</au><au>Lee, S. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis</atitle><jtitle>Neuropathology and applied neurobiology</jtitle><addtitle>Neuropathol Appl Neurobiol</addtitle><date>2004-06</date><risdate>2004</risdate><volume>30</volume><issue>3</issue><spage>233</spage><epage>242</epage><pages>233-242</pages><issn>0305-1846</issn><eissn>1365-2990</eissn><coden>NANEDL</coden><abstract>IL‐16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti‐HIV‐1 activities. We determined IL‐16 expression in human brain tissue with HIV‐1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL‐16. IL‐16 immunoreactivity was particularly pronounced in microglial nodules. In vitro, human foetal microglia and not astrocytes produce IL‐16, and HIV‐1 infection up‐regulates microglial IL‐16 release in a Nef‐dependent manner. These results support the notion that, in the brain, IL‐16 is a macrophage‐lineage specific modulator of the inflammatory response and HIV‐1 expression. Recruitment of IL‐16+ T cells and microglia/macrophages may represent an innate response to HIV‐1 infection in the central nervous system that counterbalances viral stimulatory factors.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15175077</pmid><doi>10.1046/j.0305-1846.2003.00527.x</doi><tpages>10</tpages></addata></record> |
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| subjects | AIDS Dementia Complex - genetics AIDS Dementia Complex - metabolism astrocyte Astrocytes - metabolism Biological and medical sciences Brain - pathology Cells, Cultured chemokine HIV-1 Human immunodeficiency virus 1 Humans Immunohistochemistry Interleukin-16 - biosynthesis Interleukin-16 - genetics Lipopolysaccharides - pharmacology Lymphocytes - metabolism macrophage Medical sciences Microglia - metabolism microglial nodule Nef Neurology Paraffin Embedding Stimulation, Chemical T-Lymphocytes - metabolism Tissue Fixation |
| title | IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis |
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