A case study in the treatment of dementia with Lewy bodies
Objective: To describe the assessment and treatment of an elderly woman with parkinsonism, progressive memory and cognitive deficits, and visual hallucinations. Method: The patient presented with a 10‐year history of hand tremors, an 8‐year history of short‐term memory problems, and a 3–4‐year hist...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2004-07, Vol.110 (1), p.73-75 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Kaufer, Daniel I. |
| description | Objective: To describe the assessment and treatment of an elderly woman with parkinsonism, progressive memory and cognitive deficits, and visual hallucinations.
Method: The patient presented with a 10‐year history of hand tremors, an 8‐year history of short‐term memory problems, and a 3–4‐year history of visual hallucinations. Treatment with donepezil and rivastigmine (successively) did not produce the desired benefits. Then she was started on galantamine 4 mg b.i.d. (escalated to 8 mg b.i.d.).
Results: The patient's social interaction improved and cognitive decline appeared to be stabilized; hallucinations and agitation were also better controlled.
Conclusion: By current criteria, this subject would be labeled as having Parkinson's disease with dementia, although she exhibited the core features of dementia with Lewy body disease. As suggested in previous studies, cholinesterase inhibitors may be effective in treating psychotic symptoms; however, all currently available agents may not be equally effective. |
| doi_str_mv | 10.1111/j.1600-0447.2004.00323.x |
| format | Article |
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Method: The patient presented with a 10‐year history of hand tremors, an 8‐year history of short‐term memory problems, and a 3–4‐year history of visual hallucinations. Treatment with donepezil and rivastigmine (successively) did not produce the desired benefits. Then she was started on galantamine 4 mg b.i.d. (escalated to 8 mg b.i.d.).
Results: The patient's social interaction improved and cognitive decline appeared to be stabilized; hallucinations and agitation were also better controlled.
Conclusion: By current criteria, this subject would be labeled as having Parkinson's disease with dementia, although she exhibited the core features of dementia with Lewy body disease. As suggested in previous studies, cholinesterase inhibitors may be effective in treating psychotic symptoms; however, all currently available agents may not be equally effective.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.2004.00323.x</identifier><identifier>PMID: 15180783</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Aged ; Aged, 80 and over ; Carbamates - therapeutic use ; cholinesterase inhibitors ; Cognition Disorders - drug therapy ; Cognition Disorders - etiology ; Drug Resistance ; Female ; galantamine ; Galantamine - therapeutic use ; Hallucinations - drug therapy ; Hallucinations - etiology ; Humans ; Indans - therapeutic use ; Lewy body disease ; Lewy Body Disease - complications ; Lewy Body Disease - drug therapy ; Lewy Body Disease - psychology ; Neuroprotective Agents - therapeutic use ; Nootropic Agents - therapeutic use ; parkinsonian disorders ; Phenylcarbamates ; Piperidines - therapeutic use ; Psychomotor Agitation ; Rivastigmine ; Social Behavior</subject><ispartof>Acta psychiatrica Scandinavica, 2004-07, Vol.110 (1), p.73-75</ispartof><rights>Copyright Blackwell Munksgaard 2004.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3653-b82848857c253fdcbdf0c7b32d0faaa8c3c219141a5d25d22b1f93704165596c3</citedby><cites>FETCH-LOGICAL-c3653-b82848857c253fdcbdf0c7b32d0faaa8c3c219141a5d25d22b1f93704165596c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2004.00323.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2004.00323.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15180783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaufer, Daniel I.</creatorcontrib><title>A case study in the treatment of dementia with Lewy bodies</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: To describe the assessment and treatment of an elderly woman with parkinsonism, progressive memory and cognitive deficits, and visual hallucinations.
Method: The patient presented with a 10‐year history of hand tremors, an 8‐year history of short‐term memory problems, and a 3–4‐year history of visual hallucinations. Treatment with donepezil and rivastigmine (successively) did not produce the desired benefits. Then she was started on galantamine 4 mg b.i.d. (escalated to 8 mg b.i.d.).
Results: The patient's social interaction improved and cognitive decline appeared to be stabilized; hallucinations and agitation were also better controlled.
Conclusion: By current criteria, this subject would be labeled as having Parkinson's disease with dementia, although she exhibited the core features of dementia with Lewy body disease. As suggested in previous studies, cholinesterase inhibitors may be effective in treating psychotic symptoms; however, all currently available agents may not be equally effective.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carbamates - therapeutic use</subject><subject>cholinesterase inhibitors</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - etiology</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>galantamine</subject><subject>Galantamine - therapeutic use</subject><subject>Hallucinations - drug therapy</subject><subject>Hallucinations - etiology</subject><subject>Humans</subject><subject>Indans - therapeutic use</subject><subject>Lewy body disease</subject><subject>Lewy Body Disease - complications</subject><subject>Lewy Body Disease - drug therapy</subject><subject>Lewy Body Disease - psychology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Nootropic Agents - therapeutic use</subject><subject>parkinsonian disorders</subject><subject>Phenylcarbamates</subject><subject>Piperidines - therapeutic use</subject><subject>Psychomotor Agitation</subject><subject>Rivastigmine</subject><subject>Social Behavior</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN9LwzAQx4Mobk7_BcmTb62XpGlTwYcx_AUDBRV8C2mSso521SZl639v6oa-ehzcHff93sEHIUwgJiGu1zFJASJIkiymAEkMwCiLd0do-rs4RlMAIFGaw8cEnTm3DiMnIE7RhHAiIBNsim7mWCtnsfO9GXC1wX5lse-s8o3deNyW2NixqxTeVn6Fl3Y74KI1lXXn6KRUtbMXhzpD7_d3b4vHaPn88LSYLyPNUs6iQlCRCMEzTTkrjS5MCTorGDVQKqWEZpqSnCREcUND0oKUOcsgISnnearZDF3t73527VdvnZdN5bSta7Wxbe9kRvKcBUMQir1Qd61znS3lZ1c1qhskATlyk2s54pEjHjlykz_c5C5YLw8_-qKx5s94ABUEt3vBtqrt8O_Dcr54eQ0d-wYFx3n5</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Kaufer, Daniel I.</creator><general>Munksgaard International Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>A case study in the treatment of dementia with Lewy bodies</title><author>Kaufer, Daniel I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3653-b82848857c253fdcbdf0c7b32d0faaa8c3c219141a5d25d22b1f93704165596c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carbamates - therapeutic use</topic><topic>cholinesterase inhibitors</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - etiology</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>galantamine</topic><topic>Galantamine - therapeutic use</topic><topic>Hallucinations - drug therapy</topic><topic>Hallucinations - etiology</topic><topic>Humans</topic><topic>Indans - therapeutic use</topic><topic>Lewy body disease</topic><topic>Lewy Body Disease - complications</topic><topic>Lewy Body Disease - drug therapy</topic><topic>Lewy Body Disease - psychology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Nootropic Agents - therapeutic use</topic><topic>parkinsonian disorders</topic><topic>Phenylcarbamates</topic><topic>Piperidines - therapeutic use</topic><topic>Psychomotor Agitation</topic><topic>Rivastigmine</topic><topic>Social Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaufer, Daniel I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaufer, Daniel I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case study in the treatment of dementia with Lewy bodies</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2004-07</date><risdate>2004</risdate><volume>110</volume><issue>1</issue><spage>73</spage><epage>75</epage><pages>73-75</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><abstract>Objective: To describe the assessment and treatment of an elderly woman with parkinsonism, progressive memory and cognitive deficits, and visual hallucinations.
Method: The patient presented with a 10‐year history of hand tremors, an 8‐year history of short‐term memory problems, and a 3–4‐year history of visual hallucinations. Treatment with donepezil and rivastigmine (successively) did not produce the desired benefits. Then she was started on galantamine 4 mg b.i.d. (escalated to 8 mg b.i.d.).
Results: The patient's social interaction improved and cognitive decline appeared to be stabilized; hallucinations and agitation were also better controlled.
Conclusion: By current criteria, this subject would be labeled as having Parkinson's disease with dementia, although she exhibited the core features of dementia with Lewy body disease. As suggested in previous studies, cholinesterase inhibitors may be effective in treating psychotic symptoms; however, all currently available agents may not be equally effective.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15180783</pmid><doi>10.1111/j.1600-0447.2004.00323.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Acta psychiatrica Scandinavica, 2004-07, Vol.110 (1), p.73-75 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Carbamates - therapeutic use cholinesterase inhibitors Cognition Disorders - drug therapy Cognition Disorders - etiology Drug Resistance Female galantamine Galantamine - therapeutic use Hallucinations - drug therapy Hallucinations - etiology Humans Indans - therapeutic use Lewy body disease Lewy Body Disease - complications Lewy Body Disease - drug therapy Lewy Body Disease - psychology Neuroprotective Agents - therapeutic use Nootropic Agents - therapeutic use parkinsonian disorders Phenylcarbamates Piperidines - therapeutic use Psychomotor Agitation Rivastigmine Social Behavior |
| title | A case study in the treatment of dementia with Lewy bodies |
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