Expression of the Hereditary Hemochromatosis Protein HFE Increases Ferritin Levels by Inhibiting Iron Export in HT29 Cells

Iron is essential for life in almost all organisms and, in mammals, is absorbed through the villus cells of the duodenum. Using a human colonic carcinoma cell line that has many duodenal characteristics, HT29, we show that genes involved in intestinal iron transport are endogenously expressed. When...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2004-06, Vol.279 (24), p.25085-25092
Hauptverfasser:	Davies, Paige S., Enns, Caroline A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Biological Transport Cell Polarity Ferritins - blood Hemochromatosis Protein Histocompatibility Antigens Class I - physiology Homeostasis HT29 Cells Humans Iron - metabolism Membrane Proteins - physiology Receptors, Transferrin - physiology RNA, Messenger - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!