Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells

Tibolone (Org OD14) is a synthetic steroid used for post-menopausal hormone replacement therapy (HRT). Since HRT might increase breast cancer risk, it is important to determine the possible effects of tibolone on breast tissues. Tibolone and its metabolites Org 4094, Org 30126 and Org OM38 have been...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2002-07, Vol.81 (3), p.237-247
Hauptverfasser:	van de Ven, J, Donker, G.H, Sprong, M, Blankenstein, M.A, Thijssen, J.H.H
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - metabolism Adipose stromal cells Adipose Tissue - cytology Aromatase Aromatase - metabolism Biological and medical sciences Breast Breast - cytology Breast - pathology Breast Neoplasms - pathology Dose-Response Relationship, Drug Estradiol - metabolism Estrogen Receptor Modulators - metabolism Estrogen Receptor Modulators - pharmacology Estrogens - metabolism Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Ligands Mammary gland diseases MCF-7 Medical sciences Models, Chemical Norpregnenes - metabolism Norpregnenes - pharmacology Org 2058 Org 30126 Org 4094 Org OM38 Protein Binding Receptors, Progesterone Stromal Cells - enzymology Sulfatase Sulfatases - metabolism T47D Tibolone Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!